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CASP12 — RELA

Text-mined interactions from Literome

Chakravortty et al., Infect Immun 2001 : Similarly, a caspase 3-specific inhibitor, Z-Asp-Glu-Val-Asp-fluoromethylketone, inhibited NO production, NF-kappaB activation, and JNK/SAPK phosphorylation in LPS stimulated RAW cells
Neuzil et al., Biochemistry 2001 (Inflammation) : Our data infer a pathway by which caspase activation in EC inhibits NF kappa B-dependent inflammatory activation and monocyte recruitment, and provide evidence for a relationship between pro-apoptotic and anti-inflammatory pathways
Yang et al., Am J Physiol Gastrointest Liver Physiol 2001 (Fatty Liver) : Fatty liver vulnerability to endotoxin induced damage despite NF-kappaB induction and inhibited caspase 3 activation
Kühn et al., Arthritis Rheum 2001 : These results suggest that CD95 dependent cell death is enhanced by NF-kappaB inhibition at and/or downstream of caspase 8 activation and that caspase 9 activation is not involved in CD95 mediated apoptosis in chondrocytes
Hu et al., Cancer Res 2001 (Leukemia, Myeloid...) : Although Bay 11-7085 prevented phorbol 12-myristate 13-acetate induced NF-kappaB nuclear translocation, SN50, a specific inhibitor of nuclear translocation and function of NF-kappaB , did not induce any significant nuclear/DNA fragmentation, caspase 3 activation, or cell death
Kim et al., J Neurosci 2001 (Spinal Cord Injuries...) : NF-kappaB transactivates c-IAP2 to inhibit caspase-3 activation
Bernal et al., Blood 2001 (Leukemia, Lymphocytic, Chronic, B-Cell) : The response includes inhibition of caspase activity, activation of NF-kappaB , and expression of mcl-1, bcl-2, and bfl-1 in the tumor cells
Cahir-McFarland et al., Recent Results Cancer Res 2002 (Cell Transformation, Viral) : NF-kappaB inhibition caused caspase 3 and 8 activation, PARP cleavage, and DNA fragmentation indicative of apoptosis
Chen et al., J Dent Res 2002 (Carcinoma, Squamous Cell...) : Additionally, we found that the inhibition of NFkappaB by Adv-SR-IkappaBalpha enhanced TNF mediated caspase-8 and -3 activation
Salmond et al., Eur J Immunol 2002 : CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB dependent caspase activation
Schauvliege et al., J Biol Chem 2002 : Transient transfections with caspase-11 promoter-luciferase reporter constructs and deletion/mutation analysis revealed an essential role for NF-kappaB binding in the up-regulation of caspase-11 in response to LPS
Gumucio et al., Clin Exp Rheumatol 2002 (Autoimmune Diseases...) : ASC itself participates in at least three important cellular processes : apoptosis, recruitment and activation of pro-caspase-1 ( with associated processing and secretion of IL-1beta ), and activation of NF-kappaB ( a transcription factor involved in both initiation and resolution of the inflammatory response )
Shimada et al., Mol Carcinog 2002 (MAP Kinase Signaling System...) : We found that NFkappaB activation inhibited c-jun NH ( 2 ) -terminal kinase and caspase 3 activation induced by 4-HPR and that NFkappaB inhibition by the I kappa B alpha phosphorylation inhibitor compound Bay 117082 resulted in increasing sensitization of both PC-3 and DU145 lines to apoptosis induced by 4-HPR at low concentrations
Nitta et al., Cell Signal 2003 (Cell Transformation, Viral) : Moreover, LMP1 induced activation of caspase-3 via the activation of NF-kappaB
Shikama et al., Eur J Immunol 2003 : Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
Kim et al., Am J Physiol Gastrointest Liver Physiol 2003 (Helicobacter Infections) : The suppression of NF-kappaB significantly increased caspase-3 activity and apoptosis in H. pylori infected MKN-45 and Hs746T gastric epithelial cell lines as well as primary gastric epithelial cells
Lagunoff et al., Int Rev Immunol 2003 : Virally encoded genes inhibit the activation of caspase-8 by the TNF receptor and Fas ; activate NF-kappaB to increase expression of antiapoptotic genes ; inhibit interferon response ; bind to p53, thereby blocking p53 dependent apoptosis ; and interact with other pro- and antiapoptotic cellular genes
Deng et al., Cell 2003 : While activation of caspase 8 is required for TNFalpha induced apoptosis, and induction of NF-kappaB inhibits cell death, the precise function of JNK activation in TNFalpha signaling is not clearly understood
Cardoso et al., Free radical research 2003 (Alzheimer Disease) : In this study, we analyzed if NF-kB activation prevented cells from caspases-activation and we also observed that inhibition of NF-kB by PDTC induced an increase in caspase-3 and caspase-6 activation
Lamkanfi et al., J Biol Chem 2004 (MAP Kinase Signaling System) : In contrast to pro-IL-1beta maturation, caspase-1 induced NF-kappaB activation is not inhibited by the virus derived caspase-1 inhibitor cytokine response modifier A and is equally induced by the enzymatically inactive caspase-1 C285A mutant ... We demonstrate that caspase-1 interacts with RIP2 and that dominant negative forms of RIP2 and IkappaB kinase complex-beta inhibit caspase-1 mediated NF-kappaB activation
Hentze et al., Hepatology 2004 : CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2, FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Jiménez Del Río et al., Arch Med Res 2004 (Necrosis...) : Further evaluations comprised production of H2O2, generation of hydroxyl radical ( .OH ), disruption of mitochondrial transmembrane potential ( DeltaPsim ), caspase-3 activation, and activation of NF-kappaB and p53 transcriptional factors ... All metals induced mitochondrial depolarization ( 17-62 % nonfluorescent cells ) and activated caspase-3 concomitantly with apoptotic morphology ( 25-32 % AO/EB ) at 24 h, and neither NF-kappaB nor p53 transcription factor showed activation
Tantini et al., Amino Acids 2004 (MAP Kinase Signaling System) : Moreover, pharmacological NF-kappaB inhibition reduced the increase in caspase activity and cell death elicited by etoposide, suggesting that NF-kappaB is involved in signaling to apoptosis
Damiano et al., J Immunol 2004 : NAIP CIIA HET-E and TP1 (NACHT) family proteins are involved in sensing intracellular pathogens or pathogen derived molecules, triggering host defense responses resulting in caspase mediated processing of proinflammatory cytokines and NF-kappaB activation
Jun et al., Oncogene 2005 : Role of FLASH in caspase-8 mediated activation of NF-kappaB : dominant negative function of FLASH mutant in NF-kappaB signaling pathway ... Here, we addressed the role of endogenous caspase-8 in tumor necrosis factor (TNF)-alpha induced activation of NF-kappaB ... Instead, caspase-8 ( D73A ) mutant bound to caspase-8 and blocked NF-kappaB activation triggered by TNF-alpha and caspase-8 ... Taken together, these results suggest that endogenous caspase-8 mediates TNF-alpha induced activation of NF-kappaB via FLASH
Moriuchi et al., Cancer Gene Ther 2005 (Brain Neoplasms...) : Following infection with TOIkappaB, nuclear translocation of NF-kappaB in U-87MG cells was significantly inhibited and caspase-3 activity increased compared with TOZ.1 infected cells
Hasegawa et al., J Biol Chem 2005 (Inflammation) : ASC mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP ... The catalytic activity of caspase-8 was required for the ASC mediated NF-kappaB activation when caspase-8 was expressed at an endogenous level, although it was not essential when caspase-8 was overexpressed
Su et al., Science 2005 (Immunologic Deficiency Syndromes) : Requirement for caspase-8 in NF-kappaB activation by antigen receptor
Dohrman et al., J Immunol 2005 : Cellular FLIP ( long form ) regulates CD8+ T cell activation through caspase-8 dependent NF-kappa B activation
Cacicedo et al., Diabetes 2005 (Diabetic Retinopathy) : Furthermore, inhibition of NF-kappaB activation by various means inhibited caspase-3 activation
Yip et al., J Bone Miner Res 2005 (Calcium Signaling) : In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through the regulation of ROS production, caspase-3 activity, cytosolic Ca2+, and RANKL induced activation of NF-kappaB and AP-1 activities
Cavin et al., Mol Cancer Res 2005 (Carcinoma, Hepatocellular...) : Lastly, we show that NF-kappaB inhibits c-Myc induced activation of caspase-9 and caspase-3 through up-regulation of the antiapoptotic target genes Bcl-X ( L ) and X-linked inhibitor of apoptosis (XIAP)
Tang et al., Cancer Biol Ther 2005 : In the March 2005 issue of Science ( 2005 ; 307 : 1465-8 ), Su et al. provide compelling evidence supporting a role for caspase-8 in antigen receptor induced NF-kappaB activation
Takahashi et al., Genes Cells 2005 (Pancreatic Neoplasms) : We found that both NF-kappaB activation and Bcl-2 family proteins could prevent the 53BP2S mediated depression of mitochondrial transmembrane potential, activation of caspase-9 , cleavage of poly ADP ribose polymerase ( PARP ), and cell death
Ma et al., J Biol Chem 2005 : When NF-kappaB activation was inhibited by a super-repressor, IkappaBalpha, the TLR4 ligand lipopolysaccharide induced the activation of caspase 8, the loss of mitochondrial transmembrane potential ( DeltaPsim ), and apoptotic cell death in macrophages
Albee et al., Inflamm Res 2006 (Inflammation) : E. coli infection induces caspase dependent degradation of NF-kappaB and reduces the inflammatory response in macrophages ... Inhibition of caspase activity resulted in increased DNA binding activity of NF-kappaB and enhanced production of NF-kappaB dependent reporter gene expression following infection ... Further, suppression of caspase activity reduced the proteolytic cleavage of NF-kappaB ... These data indicate that infection of macrophages with E. coli induces a caspase dependent inhibition of NF-kappaB that results in a reduced production of pro-inflammatory cytokines and impaired clearance of bacteria
He et al., J Biol Chem 2006 : TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB
Dieperink et al., Pediatr Res 2006 (Hyperoxia) : Inhibition of NF-kappaB prevented the hyperoxia induced activation of caspase 3
Hu et al., Mol Cell Biol 2006 (Breast Neoplasms...) : We found, however, that inhibiting NF-kappaB significantly decreased ER stress induced cell death in a caspase-8 dependent manner
Khera et al., Lab Invest 2006 : Culture of cells in the presence of 25 mM D-glucose ( i ) enhanced apoptosis stimulated by serum depletion, ( ii ) enhanced activation of caspase-3 , ( iii ) inhibited NF-kappaB activation, and ( iv ) decreased Bcl-2 : Bax ratio
Mohan et al., J Biol Chem 2006 (Colonic Neoplasms) : The upstream activation of caspase-2 is not dependent on its antioxidant property or NF-kappaB inhibition
Lamkanfi et al., J Cell Biol 2006 : Caspases leave the beaten track : caspase mediated activation of NF-kappaB
Eisner et al., FEBS Lett 2006 : We conclude that hyperosmotic stress activates p65 and RelB NFkappaB isoforms and NFkappaB mediates caspase 9 activation in cardiomyocytes
Wong et al., Clin Immunol 2006 : Fas ( CD95 ) ligation inhibits activation of NF-kappa B by targeting p65-Rel A in a caspase dependent manner ... The inhibition is caspase dependent since an inhibitor of caspase activation, DEVD, can block the suppression of NF-kappaB activity following crosslinking of Fas
Han et al., Free Radic Biol Med 2006 : The TNF induced apoptosis seems to occur only in a certain redox range -- in which redox changes can inhibit NF-kappaB activity but not completely inhibit caspase activity
Jiang et al., FASEB J 2006 (Colonic Neoplasms...) : Stable expression of IKBSR, a known repressor of NF-kappaB activation, and cellular caspase-8-like inhibitory protein ( cFLIP ) inhibited activation of NF-kappaB in cancer cell media treated muscle cells with an accompanying enhancement of myogenic protein expression and differentiation
Kilpatrick et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : delta-PKC associates with TNFR-1 in response to TNF and is required for NFkappaB activation and inhibition of caspase 3
Oh et al., J Biomed Sci 2007 : HeLa cells treated with phytoglycoprotein ( 150 kDa ) were killed by activation of caspase 3 via inhibitory activities of NF-kappaB and AP-1
Lemmers et al., J Biol Chem 2007 (Rhabdoviridae Infections) : Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling
Ou et al., Arch Toxicol 2007 : Furthermore, several apoptotic signaling pathways which showed NF-kappaB activation, increased cytosolic calcium, alteration of mitochondrial membrane potential, cytochrome c release and activation of caspase 3 were also investigated
Miggin et al., Proc Natl Acad Sci U S A 2007 : NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 ... However, we found that Mal was cleaved by caspase-1 and that inhibition of caspase-1 activity blocked TLR2- and TLR4 mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or TLR7 signaling, which are Mal independent
He et al., Cell Signal 2007 : NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin ... NF-kappaB inhibition by Pro1, dominant negative mutant IkappaBalpha ( S32/36 ) or p65 ( N250 ), however, induced the caspase-3 activation in the normal cells, indicating the role of ATM mediated NF-kappaB activation against cell apoptosis
Misra et al., J Biol Chem 2007 (Alstrom Syndrome) : Consistent with this observation, inhibition of caspase activity attenuates NF-kappaB activation
Zhao et al., Exp Hematol 2007 (Lymphoma, B-Cell) : In addition, SAHA induced IkappaBalpha cleavage to a stable inhibitory form and caused NF-kappaB degradation in response to caspase-3 activation
Wang et al., Biochim Biophys Acta 2007 : We further show that overexpression of caspase-10g dramatically enhances NF-kappaB activity in a dose- and time dependent manner
Cruz et al., Infect Immun 2008 (Inflammation...) : Our combined results demonstrate that B. burgdorferi confined to phagolysosomes is a potent inducer of cytosolic signals that result in ( i ) production of NF-kappaB dependent cytokines, ( ii ) assembly of the inflammasome and activation of caspase-1 , and ( iii ) induction of programmed cell death
Lee et al., Mol Cancer Ther 2007 (Colonic Neoplasms) : In addition, caspase-3 inhibitor reduced epothilone B-induced cell death and NF-kappaB activation
Bhoopathi et al., J Biol Chem 2008 (MAP Kinase Signaling System...) : ERK inhibition, using a kinase-dead mutant for ERK, ameliorated NF-kappaB activation and caspase mediated apoptosis in Ad-MMP-9 infected cells
Kersse et al., Biochem Soc Trans 2007 (Inflammation) : Furthermore, we discuss the functional characteristics of the caspase-1 related CARD-only proteins in relation to caspase-1 mediated IL-1beta maturation and NF-kappaB activation
Lakshmanan et al., J Immunol 2007 : Because a specific NF-kappaB inhibitor blocked LPS induced IL-8 and CCL4 mRNA expression as well as IL-8 and CCL4 secretion in THP1 cells, we investigated the role of caspase-4 in NF-kappaB signaling
Hinshaw-Makepeace et al., Eur J Immunol 2008 : Effective stimulation of NF-kappaB in T cells following TCR ligation requires the activity of caspase-8
Chuang et al., In Vivo 2007 (Uterine Cervical Neoplasms) : Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation
Gartner et al., Vaccine 2008 : Transient transfection showed that the mutated caspase induced slow apoptosis, normal protein expression and NF-kappaB activation while wild-type caspase induced rapid apoptosis, lower protein expression and no NF-kappaB activation
Al-Lamki et al., J Am Soc Nephrol 2008 (Nephritis) : Inhibition of NF-kappaB activation increased TL1A mediated caspase-3 activation and apoptosis of TEC, but it did not reduce the induction of TNFR2
Ballaun et al., Biochem Biophys Res Commun 2008 : Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB ... Our data reveal the basic organization of the human caspase-14 promoter and suggest an important role of AP-1 and NFkappaB in the transcriptional control of caspase-14
Bren et al., PloS one 2008 (Alstrom Syndrome) : Given the independent observations that acute T cell HIV-1 infection results in ( 1 ) NF-kappaB activation, ( 2 ) caspase 8 dependent apoptosis, and that ( 3 ) caspase 8 directly activates NF-kappaB , we questioned whether these three events might be interrelated ... Finally, we demonstrate that the HIV protease cleavage of caspase 8 is necessary for optimal NF-kappaB activation and that the HIV-1 protease specific cleavage fragment Casp8p41 is sufficient to stimulate HIV-1 replication through NF-kappaB dependent HIV-LTR activation both in vitro as well as in cells from HIV infected donors
Kin et al., Shock 2008 : Compared with Control, Postcon also inhibited translocation of NF-kappa B to nuclei ( 167 % +/- 21 % vs. 142 % +/- 18 % * ), decreased the level of plasma TNF-alpha ( 1,994 +/- 447 vs. 667 +/- 130* pg/mL ), and inhibited caspase-3 activity ( 0.57 % +/- 0.1 % vs. 0.21 % +/- 0.1 % * )
Chae et al., Blood 2008 (Familial Mediterranean Fever) : The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
Bednarski et al., Mol Cancer Ther 2008 : The inhibition of doxorubicin induced NF-kappaB activation by the knockdown of either catalytic subunit resulted in increased cleaved caspase-3 and cleaved poly ( ADP-ribose ) polymerase and increased apoptosis when compared with doxorubicin alone
Pacheco-Palencia et al., J Agric Food Chem 2008 (Skin Diseases) : Pomegranate extract ( PE ), in a range from 5 to 60 mg/L, was effective at protecting human skin fibroblasts from cell death following UV exposure, likely related to a reduced activation of the pro-inflammatory transcription factor NF-kappaB , a downregulation of proapoptotic caspase-3 , and an increased G0/G1 phase, associated with DNA repair
Maelfait et al., Biochem Pharmacol 2008 : Here we review the role of caspase-8 in embryonic development, monocyte differentiation, T and B cell proliferation, and the activation of NF-kappaB
Moon et al., Cancer Lett 2009 (Neoplasms) : Sulforaphane suppresses TNF-alpha mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species dependent caspase-3 ... In conclusion, the results of the present study indicate that SFN suppresses TNF-alpha induced NF-kappaB activity and induces apoptosis through activation of ROS dependent caspase-3
Zhang et al., Clin Exp Pharmacol Physiol 2009 (Adrenal Gland Neoplasms...) : The inhibition of NF-kappaB by TPCK enhanced caspase 3 activity induced by 300 micromol/L H(2)O ( 2 )
Mustonen et al., Dig Dis Sci 2009 : Taurocholate potentiates ethanol induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells
Kim et al., Bone 2009 (Bone Resorption) : Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK
Shan et al., Mol Cell Biochem 2009 : Interestingly, our data demonstrated that RIOK3 suppressed caspase-10 mediated NF-kappaB activation by competing RIP1 and NIK to bind to caspase-10
Montecucco et al., J Biomed Biotechnol 2009 (Inflammation) : Oxaprozin pro-apoptotic activity was associated with the inhibition of CD40L triggered Akt and NF-kappaB phosphorylation and the activation of caspase 3
Connelly et al., J Cell Physiol 2010 (Disease Models, Animal...) : We found that activation of NF-kappaB during involution resulted in a more rapid reduction in milk levels and increased cleavage of caspase-3 , an indicator of apoptosis
Harder et al., J Immunol 2009 (Disease Models, Animal...) : These results indicate that caspase-1 activation in response to S. pyogenes infection requires NF-kappaB and the virulence factor streptolysin O, but proceeds independently of P2X7R and TLR signaling
Henrotin et al., Osteoarthritis Cartilage 2010 (Inflammation...) : Curcumin blocks IL-1beta induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3
Chang et al., Experimental biology and medicine (Maywood, N.J.) 2009 : The proteolytic activity of caspase 8 was required for the NF-kappaB activity
Roccaro et al., Blood 2010 (Lymphoma...) : Primary WM cells express higher level of i20S compared with c20S, and that ONX0912 inhibited the CT-L activity of both i20S and c20S, leading to induction of toxicity in primary WM cells, as well as of apoptosis through c-Jun N-terminal kinase activation, nuclear factor kappaB (NF-kappaB) inhibition , caspase cleavage, and initiation of the unfolded protein response
Park et al., Toxicol In Vitro 2010 (Carcinoma, Squamous Cell...) : These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB
Liang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 : The expression levels of caspase-3 and bax after co-treatment of GA and Fe3O4-MNP were higher than that exposed to GA or Fe3O4-MNP alone, but the expressions of bcl-2, NF-kappaB and survivin were down-regulated
Ehrenschwender et al., Cell Death Differ 2010 (Neoplasm Invasiveness) : NFkappaB activation and adoption of amoeboid shape were inhibited by caspase-8 knockdown or FLIP-S expression, but only the cell morphology alterations required caspase-8 activity
Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 : The mechanism of apoptosis may be related to the down-regulation of the expression of NF-kappaB and the activation of caspase 3
Wang et al., Microb Pathog 2010 : Collectively, these data define a pathway that infection of primary monocytes and U937 cells with S. aureus induces a caspase dependent inhibition of NF-kappaB
Pyo et al., J Neurosci Res 2010 (Neuroblastoma) : Our results suggest that glutamate excitotoxicity in motor neurons of SOD1 linked fALS is attributable, at least in part, to the impairment of IkappaBalpha dependent RelA activation and subsequent apoptosis mediated by XIAP inhibition and caspase-3 activation
Wu et al., Biochem Cell Biol 2010 (Carcinoma, Hepatocellular...) : Inhibition of NF-kappaB by PDTC decreased NF-kappaB p65 expression, enhanced cell apoptosis ratio, and increased caspase-3 activity
Frank et al., Mol Cell Biol 2011 (Inflammation) : We show that caspase 4/11 requires both p53 and NF-?B for full induction after DNA damage and that the P72 variant shows increased interaction with p65 RelA , a subunit of NF-?B
Gentle et al., J Biol Chem 2011 : In TNF stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
Oh et al., J Pharmacol Exp Ther 2011 (Inflammation...) : In activated human mast cells, the receptor interacting protein 2 (RIP2), I?B kinase ( IKK ) -ß, nuclear factor-?B ( NF-?B ) /RelA, and caspase-1 activation were increased, but increased RIP2, IKK-ß, NF-?B/RelA , and caspase-1 activation were inhibited by the treatment of IPT
Langone et al., Int J Cancer 2012 (Brain Neoplasms...) : Furthermore, overexpression of NF-kB in the B16F10 cells blocked adduct evoked stimulation of caspase-3/7 activity