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HES2 — RELA
Text-mined interactions from Literome
Lv et al., Acta Anaesthesiol Scand 2005
:
Similarly,
HES could
inhibit hepatic
NF-kappaB and AP-1 activations
Lv et al., Ann Clin Lab Sci 2005
(Sepsis) :
HES also down-regulated pulmonary proinflammatory cytokines ( TNF-alpha, IL-1beta, and IL-6 ) and mRNA expressions ( CINC and P-selectin ), and
inhibited pulmonary activities of
NF-kappaB and AP-1
Lv et al., J Int Med Res 2005
(Endotoxemia...) :
HES also decreased the number of MPO positive cells induced by LPS and
inhibited activation of
NF-kappaB and AP-1
Tian et al., Acta Anaesthesiol Scand 2005
:
3.75 and 7.5 ml/kg
HES suppressed LPS induced
NF-kappaB activation in the four tissues and decreased plasma TNF-alpha elevation
Wang et al., Int Immunopharmacol 2009
(Disease Models, Animal...) :
In addition, both
HES and BL could
attenuate the increase in TNF-alpha, IL-6, MPO levels and
NF-kappaB activation
Feng et al., Int Immunopharmacol 2010
(Disease Models, Animal...) :
Meanwhile,
HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA,
inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain
Xie et al., Ann Clin Lab Sci 2010
(Endotoxemia) :
The infusion of HES130/0.4 in endotoxemic rats, especially 15 ml/kg, significantly reduced the release of plasma TNF-alpha and IL-1beta, which was consistent with the observed inhibitory
effects of
HES130/0.4 on
NF-kappaB activation, TLR4 mRNA expression, and TLR4 protein level in monocytes