◀ Back to RELA

PPP2CA — RELA

Pathways - manually collected, often from reviews:

• KEGG Chagas disease (American trypanosomiasis): NFKB1/RELA → PPP2CA/PPP2CB/PPP2R1A/PPP2R1B/PPP2R2A/PPP2R2B/PPP2R2C/PPP2R2D (protein-protein, activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PPP2CA — RELA (direct interaction, pull down) Yang et al., J Biol Chem 2001*
• IRef Hprd Interaction: RELA — PPP2CA (in vitro) Yang et al., J Biol Chem 2001*, Sakurai et al., J Biol Chem 2003*
• IRef Intact Interaction: PPP2CA — RELA (dephosphorylation reaction, phosphatase assay) Yang et al., J Biol Chem 2001*
• IRef Intact Interaction: PPP2CA — RELA (physical association, pull down) Yang et al., J Biol Chem 2001*
• IRef Intact Interaction: PPP2CA — RELA (physical association, cross-linking study) Yang et al., J Biol Chem 2001*
• IRef Intact Interaction: Complex of BRAP-HES6-TWIST1-RELA-PPP2CA-SETD8 (association, pull down) Yang et al., EMBO J 2012

Text-mined interactions from Literome

Fu et al., J Biol Chem 2003 : Our data support the notion that IKK gamma associated PP2A is responsible for the rapid deactivation of IKK, and inhibition of PP2A by Tax in the context of IKK x PP2A x Tax ternary complex leads to constitutive IKK and NF-kappa B activation
Hong et al., J Biol Chem 2007 : Interestingly, peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and IKKgamma-PP2A interactions and potently inhibit NF-kappaB activation by Tax and tumor necrosis factor-alpha
Trotta et al., J Exp Med 2007 : Further, SET knockdown or pharmacologic activation of PP2A diminished extracellular signal regulated kinase 1/2, p65RelA , signal transducer and activator of transduction 4 ( STAT4 ), and STAT5 activity in monokine stimulated NK cells, potentially contributing to the reduction in IFN-gamma gene expression
Marasa et al., Am J Physiol Cell Physiol 2008 : The present study tests the hypothesis that induced TRPC1 expression inhibits NF-kappaB activation by increasing PP2A activity through Ca2+ influx in IECs ... Inhibition of PP2A activity by treatment with okadaic acid or PP2A silencing with small interfering RNA not only enhanced NF-kappaB transactivation but also prevented the increased susceptibility of IEC-TRPC1 cells to apoptosis induced by treatment with tumor necrosis factor-alpha (TNF-alpha)/cycloheximide ( CHX ) ... Decreasing Ca2+ influx by exposure to the Ca2+-free medium reduced PP2A mRNA levels, destabilized PP2A proteins, and induced NF-kappaB activation, thus blocking the increased sensitivity of IEC-TRPC1 cells to TNF-alpha/CHX induced apoptosis
Sontag et al., EMBO J 1997 : Constitutive activation of PKC zeta and NF-kappaB following inhibition of PP2A supports new mechanisms by which SV40 small t promotes cell growth and transformation