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PPP2R1A — RELA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fu et al., J Biol Chem 2003
:
Our data support the notion that IKK gamma associated PP2A is responsible for the rapid deactivation of IKK, and inhibition of
PP2A by Tax in the context of IKK x PP2A x Tax ternary complex
leads to constitutive IKK and
NF-kappa B activation
Hong et al., J Biol Chem 2007
:
Interestingly, peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and
IKKgamma-PP2A interactions and potently
inhibit NF-kappaB activation by Tax and tumor necrosis factor-alpha
Trotta et al., J Exp Med 2007
:
Further, SET knockdown or pharmacologic activation of
PP2A diminished extracellular signal regulated kinase 1/2,
p65RelA , signal transducer and activator of transduction 4 ( STAT4 ), and STAT5 activity in monokine stimulated NK cells, potentially contributing to the reduction in IFN-gamma gene expression
Marasa et al., Am J Physiol Cell Physiol 2008
:
The present study tests the hypothesis that induced TRPC1 expression
inhibits NF-kappaB activation by increasing
PP2A activity through Ca2+ influx in IECs ... Inhibition of
PP2A activity by treatment with okadaic acid or PP2A silencing with small interfering RNA not only
enhanced NF-kappaB transactivation but also prevented the increased susceptibility of IEC-TRPC1 cells to apoptosis induced by treatment with tumor necrosis factor-alpha (TNF-alpha)/cycloheximide ( CHX ) ... Decreasing Ca2+ influx by exposure to the Ca2+-free medium reduced
PP2A mRNA levels, destabilized PP2A proteins, and
induced NF-kappaB activation, thus blocking the increased sensitivity of IEC-TRPC1 cells to TNF-alpha/CHX induced apoptosis
Sontag et al., EMBO J 1997
:
Constitutive
activation of PKC zeta and
NF-kappaB following inhibition of
PP2A supports new mechanisms by which SV40 small t promotes cell growth and transformation