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SKP1 — TCF15

Text-mined interactions from Literome

Meimoun et al., Mol Biol Cell 2000 : Here we report that SCF ( CDC4 ), a recently characterized protein complex that acts in conjunction with the ubiquitin conjugating enzyme Cdc34 to degrade cell cycle regulators, is also necessary for the degradation of the transcription factor Gcn4. Degradation of Gcn4 occurs throughout the cell cycle, whereas degradation of the known cell cycle substrates of Cdc34/SCF(CDC4) is cell cycle regulated
Litz et al., Mol Cancer Ther 2006 (Carcinoma, Small Cell...) : SCF increased nuclear levels of the HIF-1alpha transcription factor , which correlated well with increased HIF-1alpha binding to a consensus hypoxia-responsive element
Nakajima et al., Arch Dermatol Res 2012 (Hyperpigmentation) : Real-time RT-PCR and western blotting of Ax-treated HEEs revealed that the SCF stimulated expression of tyrosinase (TYR), TYR related protein-1 (TYRP1), and Pmel17, as well as microphthalmia associated transcription factor ( MITF ), is significantly suppressed by Ax at the transcriptional and translational levels
Wakabayashi et al., J Dermatol Sci 2013 (Lentigo) : Real-time RT-PCR and Western blotting of these NCM treated HEEs unexpectedly revealed that the EDN1+SCF stimulated steady-state levels of tyrosinase (TYR), TYR related protein-1, dopachrome tautomerase and PMEL17 as well as microphthalmia associated transcription factor ( MITF ) were significantly attenuated at the transcriptional and translational levels without any cytotoxic effects on keratinocytes and melanocytes in the HEEs