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CRK — NGF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Puntambekar et al., J Neurochem 2005
:
Inhibition of NADPH oxidase activity also attenuated
NGF dependent
p38 MAPK activation
Park et al., Mol Cells 2006
:
The
p38 mitogen activated protein kinase ( MAPK ) inhibitor, SB203580, phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294003, protein kinase A (PKA) inhibitor, H89, and protein kinase C ( PKC ) inhibitor, chelerythrine,
had no effect on activation of promoter IV by
NGF
Arien-Zakay et al., J Mol Neurosci 2007
(Neuroblastoma) :
Combined CM and
NGF treatment
induced constitutive activation of the mitogen activated protein kinases ERK2 ( 36-fold vs control ), p38alpha ( nine-fold vs control ) and
p38beta ( 23-fold vs control ), most likely related to survival and/or differentiation
Ali et al., Diabetes 2008
(Cadaver...) :
Furthermore, peroxynitrite induced neuronal death, TrkA nitration, and activation of
p38 mitogen activated protein kinase ( MAPK ) in RGCs, even in the
presence of exogenous
NGF
Yung et al., Cell Signal 2008
(MAP Kinase Signaling System) :
Induction of
p38 MAPK phosphorylation by
NGF occurred in a time- and dose dependent manner and was partially inhibited by pertussis toxin ( PTX ) ... Collectively, these studies indicate that
NGF dependent
p38 MAPK activity may be mediated via G ( i2 ) protein, Src, and the MEK/ERK cascade
Torres et al., Oncogene 1996
:
Using receptor activated immunoprecipitation followed by analysis of the immune complexes by SDS-PAGE and immunoblotting, we show that
NGF induces the association of TrkA with
c-Crk-II in a multimeric complex that also includes SHC and PLC-gamma 1
Ribon et al., J Biol Chem 1996
(Adrenal Gland Neoplasms...) :
To further explore the role of Crk in NGF induced PC-12 cell differentiation, we found that both
NGF and epidermal growth factor
stimulate the tyrosine phosphorylation of endogenous
Crk II