Gene interactions and pathways from curated databases and text-mining

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CRK — TLR4

Text-mined interactions from Literome

An et al., Immunology 2002 : Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells
Goral et al., J Immunol 2005 (Inflammation) : Acute ethanol treatment inhibited IL-6 and TNF-alpha synthesis and impaired p38 and ERK1/2 activation induced by TLR2, TLR4 , and TLR9 ligands
Maloney et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Here, we show that A52R does not inhibit TLR induced p38 or c-Jun amino N-terminal kinase (JNK) mitogen activating protein ( MAP ) kinase activation
Csóka et al., Blood 2007 : The stimulatory effect of adenosine on E coli induced IL-10 production did not require toll-like receptor 4 (TLR4) or MyD88, but was blocked by p38 inhibition
Hashimoto et al., J Cardiovasc Pharmacol 2009 : TLR4 activation increased phosphorylation of p38 mitogen activated protein kinase and decreased production of prothrombotic phosphatidylserine and P-selectin positive microparticles in response to TRAP
Zhang et al., J Neuroimmunol 2010 : In LPS treated primary SCs, retreatment with PPAR-gamma agonist remitted the increase of iNOS, p38 phosphorylation and TLR4 , MyD88, augmented the expression of PPAR-gamma and localization in nuclear
Xia et al., J Pineal Res 2012 (Inflammation) : Although it had no effect on TLR4 mediated phosphorylation of c-Jun N-terminal kinase (JNK), p38 , and extracellular regulated protein kinase ( ERK ), melatonin significantly attenuated the activation of nuclear factor kappa B ( NF-?B ) in LPS stimulated macrophages
Liu et al., PloS one 2012 (Shock, Septic) : Moreover, DCO-6 specifically inhibited TLR4 dependent p38 activation without directly inhibiting its kinase activity