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CDH2 — PI3

Text-mined interactions from Literome

Goodwin et al., J Biol Chem 2003 : In particular, homophilic cadherin ligation can directly activate Rho family GTPases and phosphatidylinositol 3-kinase ( PI3-kinase ), signaling molecules with the capacity to support the morphogenetic effects of these adhesion molecules during development and disease ... In contrast, cadherin activated PI3-kinase signaling was not affected by loss of p120-ctn binding
Owens et al., J Cell Sci 2003 (Cell Transformation, Neoplastic...) : Responsiveness to TGFbeta could be restored by inhibiting cadherin mediated cell-cell adhesion or phosphoinositide 3-kinase (PI3-K) activity, but not by inhibiting mitogen activated protein kinase ( MAPK ) activity
Kim et al., Neuroscience 2010 : Importantly, a neutralizing N-cadherin antibody inhibited BMP4 induced neurosphere attachment, astrocytic differentiation, and migration of neurosphere NSCs. Together, these findings show that BMP4 induced attachment of neurospheres is related to the astrocytic differentiation of these cells and that these effects are attributable, at least in part, to PI3 kinase-Akt pathway dependent induction of N-cadherin