Ouyang et al., Carcinogenesis 2006
(Skin Neoplasms) :
Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade
Cahill et al., J Biol Chem 2008
:
Neither inhibition of PI 3-kinase/AKT nor IKKalphaT23A overexpression affected IkappaBalpha degradation in response to IL-1