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TLR9 — TREM2
Text-mined interactions from Literome
Watarai et al., Proc Natl Acad Sci U S A 2008
:
Thus, PDC-TREM is responsible for IFN-alpha production, whereas
TLR signals are
essential for
PDC-TREM expression
Ito et al., Eur J Immunol 2012
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TREM-2 , triggering receptor expressed on myeloid cell-2, negatively
regulates TLR responses in dendritic cells
Paradowska-Gorycka et al., Hum Immunol 2013
:
Depending on the cell type,
DAP12/TREM-2 activation
plays an important role in activation and differentiation of osteoclasts, phagocytosis of bacteria, brain and bone homeostasis and inhibition of the
toll-like receptor ( TLR ) signaling in macrophages and dendritic cells