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MTOR — PIM1

Text-mined interactions from Literome

Zhang et al., Cancer Biol Ther 2009 : These results suggest that PIM1 regulates mTOR activity through phosphorylation of PRAS40
Beharry et al., Proc Natl Acad Sci U S A 2011 : Here, we find that a novel Pim kinase inhibitor, SMI-4a, or Pim-1 siRNA blocked the rapamycin-sensitive mammalian target of rapamycin ( mTORC1 ) activity by stimulating the phosphorylation and thus activating the mTORC1 negative regulator AMP dependent protein kinase (AMPK) ... Here, we find that a novel Pim kinase inhibitor, SMI-4a, or Pim-1 siRNA blocked the rapamycin-sensitive mammalian target of rapamycin ( mTORC1 ) activity by stimulating the phosphorylation and thus activating the mTORC1 negative regulator AMP dependent protein kinase (AMPK)
Walpen et al., Biochem Biophys Res Commun 2012 : Inhibition of mTOR and AKT in normal MAEC resulted in significantly elevated PIM1 protein levels in the cytosol and in the nucleus ... Thus, mTOR inhibition induced nuclear accumulation of PIM1 or expression of a nuclear C-terminal PIM1 truncation mutant is sufficient to increase endothelial cell proliferation, suggesting that nuclear localization of PIM1 is important for resistance of MAEC to rapamycin mediated inhibition of proliferation