◀ Back to MAPK13

MAPK13 — PTH

Text-mined interactions from Literome

Cole et al., Endocrinology 1999 : Parathyroid hormone activates mitogen activated protein kinase in opossum kidney cells ... In opossum kidney ( OK ) cells, activation of endogenous PTH receptors caused a time- ( peak within 15-30 min, sustained for approximately 2 h ) and dose dependent ( EC50 approximately 3 x 10 ( -10 ) M ) activation of MAPK ... Immunoblot analysis with an activation- specific MAPK antibody indicated that PTH activated both p42 and p44 MAPK ... PTH dependent MAPK activation was mimicked by the protein kinase C activator ( PKC ) phorbol myristate acetate ( PMA ), and the protein kinase A activators 8 bromo-cAMP ( 8-Br-cAMP ) and forskolin but was not affected by pertussis toxin pretreatment ... PMA or 8-Br-cAMP pretreatment blocked MAPK activation by reexposure to each kinase activator but caused no significant reduction in MAPK activation by PTH ... MAPK activation by PTH , EGF, and 8-Br-cAMP was inhibited by the MAPK kinase inhibitor PD98059 and an EGF receptor (EGFR)-selective inhibitor tyrphostin AG1478 ... EGF and PTH caused time- and AG1478-sensitive phosphorylation of the EGFR, but EGFR desensitization did not affect MAPK activation by PTH ... These data demonstrate that PTH activates MAPK and suggest that PKC, protein kinase A, and the EGFR play roles in PTH signaling
Sneddon et al., Endocrinology 2000 : In conclusion, PTH activates MAPK in both distal and proximal renal tubule cells
Gentili et al., Exp Gerontol 2000 : In the present study we analyzed whether parathyroid hormone ( rPTH [ 1-34 ] ; PTH ) stimulates the tyrosine phosphorylation of the growth related protein mitogen activated protein ( MAP ) kinases ( p42/44-MAPK ), also known as extracellular signal regulated kinases ( ERK1/2 ), in duodenal enterocytes isolated from young ( 3months ) and aged ( 24months ) rats ... Western blot analysis revealed that PTH rapidly stimulates MAPK phosphorylation ... PTH response was dose dependent ( 10 ( -11 ) -10 ( -7 ) M ) with maximal stimulation achieved at 10 ( -9 ) -10 ( -8 ) M. PTH induced MAPK phosphorylation was effectively suppressed by the tyrosine-kinase inhibitors, genistein ( 100microM ) and herbimycin ( 2microM ) ... Moreover, the tyrosine phosphorylation and activation of MAPK was dependent on Src kinase, since PP1 ( 10 and 20microM ), a specific Src family tyrosine-kinase inhibitor, blocked PTH induced MAPK activation ... In conclusion, the results obtained in this work expand our knowledge on the mechanism of action of PTH in duodenal cells, revealing that protein tyrosine phosphorylation is linked to the PTH regulation of enterocyte MAPK activation, and that this mechanism is impaired with aging
Gentili et al., Biochim Biophys Acta 2001 : As PTH activates adenylyl cyclase ( AC ) and phospholipase C and increases intracellular Ca ( 2+ ) in these cells, in the present study we evaluated the involvement of cAMP, Ca ( 2+ ) and protein kinase C ( PKC ) on PTH induced MAPK activation ... Taken together, these results indicate that cAMP and Ca ( 2+ ) play a role upstream in the signaling mechanism leading to MAPK activation by PTH in rat enterocytes ... As Ca ( 2+ ) and cAMP antagonists did not block totally PTH induced MAPK phosphorylation, it is possible that linking of the hormone signal to the MAPK pathway may additionally involve Src, which has been previously shown to be rapidly activated by PTH
Swarthout et al., Gene 2002 : It is now known that stimulation of MAPK and proliferation by PTH at low concentrations is protein kinase C ( PKC ) -dependent in both osteoblastic and kidney cells
Corbetta et al., J Clin Endocrinol Metab 2002 (Adenoma...) : A role of MAPK on PTH secretion was suggested by the finding that PD98059, a specific MEK inhibitor, abolished the inhibitory effect of 1.5 mM Ca ( o ) ( 2+ ) on PTH release from normal parathyroid cells
Gentili et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : Taken together, the present study demonstrate, for the first time, that PTH rapidly and transiently stimulates PI3K activity and its down effector Akt/PKB in rat enterocytes playing c-Src kinase a central role in PTH dependent PI3K activation and that PI3K signaling pathway contributes to PTH mediated MAPK activation
Kifor et al., J Clin Endocrinol Metab 2004 (Addison Disease...) : These anti-CaR antibodies activated the receptor based on their ability to increase inositol phosphate accumulation, activate MAPK , and inhibit PTH secretion
Hömme et al., J Am Soc Nephrol 2004 : PTH induced a persistent inhibition of p42/44 MAPK and JNK phosphorylation starting at 10 min of incubation and lasting for at least 2 h. Actinomycin D affected both p42/44 MAPK and JNK dephosphorylation by PTH, suggesting a transcription dependent mechanism of action
Buzzi et al., Biogerontology 2007 (MAP Kinase Signaling System) : PTH regulation of c-Jun terminal kinase and p38 MAPK cascades in intestinal cells from young and aged rats ... PTH did not stimulate , within 1-10 min, the basal activity and phosphorylation of p38 MAPK in rat intestinal cells
Rey et al., Bone 2007 (MAP Kinase Signaling System) : In this study we investigated whether PTH can activate p38 MAPK and the role of this kinase in osteoblastic cells
Ben-Dov et al., J Clin Invest 2007 (MAP Kinase Signaling System) : The FGF23 induced decrease in PTH secretion was prevented by a MAPK inhibitor
Lai et al., Cell Biochem Funct 2009 : Parathyroid hormone inhibits phosphorylation of mitogen activated protein kinase ( MAPK) ERK1/2 through inhibition of c-Raf and activation of MKP-1 in osteoblastic cells
Tao et al., PloS one 2011 (Bone Resorption...) : P38 mitogen activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein induced osteoclastogenesis and bone resorption
Ko et al., Translational research : the journal of laboratory and clinical medicine 2011 (MAP Kinase Signaling System) : Gene silencing of Ras-GRP1 prevented the PTH mediated suppression of NCC activity, the activation of the H-Ras isoform of Ras, and the activation of ERK1/2 MAPK
Guo et al., Chin Med J (Engl) 2010 (Fibrosis...) : A PKA activator as well as PKC activators induced MAPK phosphorylation, and both PKA and PKC inhibitors antagonized PTH induced MAPK phosphorylation and CTGF expression
Verheijen et al., J Biol Chem 1997 : Parathyroid hormone activates mitogen activated protein kinase via a cAMP mediated pathway independent of Ras ... In a previous study, we demonstrated that parathyroid hormone (PTH) inhibits mitogen activated protein ( MAP ) kinase activation in osteosarcoma cells via a protein kinase A-dependent pathway