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CREB3 — MAPK6

Text-mined interactions from Literome

Obrietan et al., Nat Neurosci 1998 : In addition, MAPK stimulation activates CREB ( cAMP response element binding protein ), indicating that potential downstream transcription factors are stimulated by the MAPK pathway in the SCN
Yan et al., Proc Natl Acad Sci U S A 1999 : D ( 2 ) receptor induced CREB phosphorylation was mediated by activation of protein kinase C and Ca ( 2+ ) /calmodulin dependent protein kinase, but not MAPK
Swart et al., J Immunol 2000 (Lymphoma, B-Cell...) : Inhibition of p38 MAPK by pretreating CH31 B cells with the highly specific bicyclic imidazole inhibitor, SB203580, reduced BCR induced CREB phosphorylation
Mitsuda et al., J Biol Chem 2001 : Conversely, constitutive expression of mitogen activated protein kinase/extracellular signal regulated kinase ( MEK ) results in activation of CREB and increased PS-1 expression that can be blocked by the addition of selective MEK inhibitors
Mayo et al., J Biol Chem 2001 : p38 MAPK/MSK-1 and protein kinase C/p90RSK pathways mediate CREB phosphorylation
Tokunou et al., Arterioscler Thromb Vasc Biol 2001 : These results suggest that the CRE site and CREB play an important role in thrombin induced IL-6 gene expression in VSMCs. Transactivation of EGF-R and activation of ERK and p38 MAPK are involved in this process
Funakoshi et al., J Biol Chem 2002 : Inhibition of epidermal growth factor-receptor by AG1478 suppressed the AngII induced CREB phosphorylation as well as activation of ERK and p38MAPK
Trümper et al., J Endocrinol 2002 (MAP Kinase Signaling System) : These interactions included : ( i ) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, ( ii ) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, ( iii ) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and ( iv ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream
Zhou et al., Biochem Biophys Res Commun 2002 : CREB DNA binding activation by a 50-Hz magnetic field in HL60 cells is dependent on extra- and intracellular Ca ( 2+ ) but not PKA, PKC, ERK, or p38 MAPK ... Furthermore, We found that the MF-induced increase of CREB DNA binding in HL60 cells was dependent on both extracellular and intracellular Ca ( 2+ ) but not PKA, PKC, ERK, or p38 MAPK by using various pathway inhibitors
Inglefield et al., Neuroscience 2002 (Synaptic Transmission) : Inhibition of mitogen activated protein kinase ( 10 microM U0126 ) or protein kinase C ( PKC ; bisindoylmaleimide, 5 microM ) activation did not inhibit A1254 induced CREB phosphorylation
Lee et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : Inhibition of ERK1/2 with PD98059 and of p38 MAPK with SB203580 efficiently blocked LPA mediated phosphorylation of CREB
Castro-Caldas et al., Mediators Inflamm 2003 : Furthermore, the cAMP antagonist, Rp-8-Br-cAMPS, and the specific p38 MAPK inhibitor, SB203580, effectively prevented both Dex induced, E2beta induced and dBcAMP induced CREB activation and ANXA1 synthesis
Gustin et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : Dominant negative CREB, an antagonist antibody directed against the type 1 TNF receptor, or pharmacological inhibition of p38 MAPK signaling blocked TNF induced CREB activation as determined by phosphorylation and gene reporter assays
Nishihara et al., J Biol Chem 2004 (Colonic Neoplasms) : Studies with pharmacological inhibitors revealed that cAMP dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A. Immunoblots and transcriptional reporter assays using specific inhibitors, as well as expression of constitutively active forms of MEK1 and MKK3, showed that c-IAP2 induction by cAMP is regulated predominantly through ERK1/2 and p38 MAPK and suggested involvement of p90 ribosomal protein S6 kinase and mitogen and stress response kinase-1 as well
Mizutani et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System...) : The p38 MAPK inhibitor, SB203580, inhibited effectively phosphorylation of HSP-27, CREB , and eIF4E in SARS-CoV infected cells
Grady et al., J Immunol 2004 (MAP Kinase Signaling System) : We also show that CREB is activated downstream of the pre-TCR complex, and that the induction of CREB activity is regulated by protein kinase C alpha- and ERK-MAPK mediated signals
Wang et al., Mol Biol Cell 2005 (Inflammation) : Moreover, the phosphatidylinositol 3 (PI3)-kinase inhibitor ( wortmannin ) and p38 ( MAPK ) inhibitor ( SB203580 ) inhibited the EGF induced CREB phosphorylation and the expression of NF-IL6beta gene in cells
Obara et al., Mol Pharmacol 2005 (Astrocytoma) : Furthermore, both CREB and IL-6 promoter activities were suppressed by SB203580 [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ], a p38 mitogen activated protein kinase ( MAPK ) inhibitor, and H89 [ N- [ 2- ( 4-bromocinnamylamino ) -ethyl ] -5-isoquinoline ], a protein kinase A (PKA) inhibitor, indicating involvements of p38 MAPK and PKA in CREB activation and IL-6 expression
Shafer et al., Biochim Biophys Acta 2005 : Clostridium difficile toxin B inhibition of small GTPases did not affect anisomycin induced COX-2 mRNA expression or phosphorylation of p38MAPK and CREB but did inhibit sorbitol dependent COX-2 expression and phosphorylation of p38MAPK and CREB
Maldonado et al., Biochem Biophys Res Commun 2005 (Calcium Signaling) : IGF-1 induced CREB phosphorylation was mediated by MEK1/ERK, PI3-K, p38-MAPK , as well as Ca ( 2+ ) /calmodulin kinase and calcineurin
Mathieson et al., Br J Pharmacol 2006 : CREB activation by SPC required both p38MAPK and CaMK activation, but not ERK1/2
Cook et al., J Mol Cell Cardiol 2006 : In contrast, expression of ECFP/AII ( intracellular AII ) in A10 VSMCs activated p38MAPK but not ERK1/2 ; inhibition of p38MAPK by SB203580 inhibited intracellular AII induced CREB phosphorylation
Ishida et al., Immunity 2006 (Leukemia, B-Cell...) : Rap1GTP induced OcaB gene activation via p38MAPK dependent Creb phosphorylation, and consistently, SPA-1 ( -/- ) immature BM B cells showing high Rap1GTP exhibited the augmented expression of OcaB and Vkappa4 genes
Park et al., Neurosci Lett 2006 (Neuroblastoma) : The mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) activates a transcription factor CREB
Miyamoto et al., J Pharmacol Sci 2006 : Furthermore, activation of CaM kinase IV and MAPK increased phosphorylation of CREB ( cyclic AMP response element binding protein ) and expression of c-Fos by stimulation of gene expression
Kundu et al., Ann N Y Acad Sci 2007 : Taken together, EGCG inhibited TPA induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK , which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo
Mao et al., Brain Res Bull 2007 : Interestingly, the PMA induced CREB phosphorylation was also blocked by a calcium/calmodulin dependent protein kinase inhibitor KN93 and the two mitogen activated protein kinase ( MAPK ) kinase inhibitors PD98059 and U0126, but not by a p38 MAPK inhibitor SB203580
Kano et al., Brain Res 2007 : Inhibition of p38 MAPK by SB203580 resulted in inhibition of the activity of the transcription factor CREB , which is activated by osmotic shock
Pham et al., J Cell Physiol 2008 : The p38 ( MAPK ) selective inhibitor, SB202190, but not the MEK selective inhibitor, PD98059, or the EGFR kinase inhibitor, AG1478, inhibited Ang II-dependent COX-2 expression and CREB phosphorylation
Martorell et al., Journal of thrombosis and haemostasis : JTH 2007 : NOR-1 up-regulation by thrombin is dependent on multiple pathways, including cytosolic Ca ( 2+ ), activation of protein kinase C ( PKC ), mitogen activated protein kinase ( MAPK ) pathways [ both extracellular regulated kinase (ERK) and p38 MAPK ], and downstream activation of cAMP response element binding protein ( CREB )
Martorell et al., Frontiers in bioscience : a journal and virtual library 2008 (Atherosclerosis...) : Mitogenic stimuli up-regulates NOR-1 in endothelial cells ( ECs ) through multiple pathways, including increase of cytosolic calcium, activation of protein kinase C, mitogen activated protein kinase ( MAPK) (ERK1/2 and p38 MAPK ) and downstream activation of cAMP response element binding protein ( CREB )
Marais et al., Cardiovasc Drugs Ther 2008 (Myocardial Reperfusion Injury) : Activation of PKA, PKC, ERK and p38 MAPK is involved in preconditioning induced CREB phosphorylation
Gavala et al., J Leukoc Biol 2008 : As P2RX7 promotes MAPK activation and inflammatory mediator production, we examined the involvement MAPK induced CREB activation in P2RX7 action
Di Giacomo et al., Int J Immunopathol Pharmacol 2009 : Regulation of CREB activation by p38 mitogen activated protein kinase during human primary erythroblast differentiation
Wang et al., Molecular cancer 2010 (Necrosis) : Our previous study has shown that the induction of dynein light chain ( DLC ) by cAMP response element binding protein ( CREB ) is required for cAMP mediated inhibition of mitogen activated protein kinase ( MAPK ) p38 activation in fibroblasts, which leads to suppression of NF-kappaB activity and promotion of tumor necrosis factor-alpha (TNF-alpha) induced cell death
Wan et al., J Interferon Cytokine Res 2010 (Neoplasms) : Activation of cAMP-responsive-element binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor ß2 in cancer cells
Begum et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and PKA/CREB mediated induction of p21, leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53, which induces MKP-1, p21, and WIP1, leading to inhibition of G1 to S cell cycle progression
Husse et al., Heart international 2010 : The inhibition of PKA, PKC, MEK, p38-MAPK or PI3-kinase partially reduced the strain induced CREB phosphorylation
Wu et al., J Biomed Sci 2011 (Hyperpigmentation...) : Cpc exerted dual antimelanogenic mechanisms by upregulation of MAPK/ERK dependent degradation of MITF and downregulation of p38 MAPK regulated CREB activation to modulate melanin formation
Deak et al., EMBO J 1998 : Mitogen- and stress activated protein kinase-1 ( MSK1 ) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
Scheid et al., Blood 1999 : A selective p38 MAPK inhibitor, SB203580, blocked TNF -- or ceramide induced CREB phosphorylation, but had no effect on the induction of apoptosis mediated by these agents