Hernández-Negrete et al., J Biol Chem 2007
:
Rapamycin, a widely used inhibitor of mTOR signaling , did not inhibit Rac activity and cell migration induced by leucine, indicating that P-Rex1, which we found associated to both mTOR complexes, is only active when in the mTORC2 complex
Dunaway et al., Mol Cell Biol 2011
:
Slit2 stimulates angiogenesis through mTORC2 dependent activation of Akt and Rac GTPase, the activities of which are inhibited in the presence of ephrin-A1