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ECM2 — PLAU
Text-mined interactions from Literome
Hapke et al., J Biol Chem 2001
(Ovarian Neoplasms) :
Because integrin signaling alters gene expression patterns, we investigated whether the expression levels of
uPA , uPAR, and PAI-1 are
affected by
ECM/integrin interactions
Elfman et al., Differentiation 2001
:
Active
uPA , in turn,
promotes increased degradation of the
extracellular matrix ( ECM ) by activation of plasminogen
Sidenius et al., Cancer Metastasis Rev 2003
(Neoplasm Invasiveness...) :
Secondly,
uPA/uPAR regulates
cell/ECM interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function
Fuhrman et al., Atherosclerosis 2012
(Atherosclerosis...) :
uPA mediate the
extracellular matrix ( ECM ) degradation, and plays a pivotal role in cell adhesion, migration and proliferation, during tissue remodeling
Gerritsen et al., Blood Cells 1993
(Arthritis, Rheumatoid...) :
TNF alpha treatment of human umbilical vein endothelial ( HUVE ) cells induced urokinase-type plasminogen (uPA) activity, increased HUVE
uPA dependent
extracellular matrix ( ECM ) degradation, and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures