Gene interactions and pathways from curated databases and text-mining

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ECM2 — PLAU

Text-mined interactions from Literome

Hapke et al., J Biol Chem 2001 (Ovarian Neoplasms) : Because integrin signaling alters gene expression patterns, we investigated whether the expression levels of uPA , uPAR, and PAI-1 are affected by ECM/integrin interactions
Elfman et al., Differentiation 2001 : Active uPA , in turn, promotes increased degradation of the extracellular matrix ( ECM ) by activation of plasminogen
Sidenius et al., Cancer Metastasis Rev 2003 (Neoplasm Invasiveness...) : Secondly, uPA/uPAR regulates cell/ECM interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function
Fuhrman et al., Atherosclerosis 2012 (Atherosclerosis...) : uPA mediate the extracellular matrix ( ECM ) degradation, and plays a pivotal role in cell adhesion, migration and proliferation, during tissue remodeling
Gerritsen et al., Blood Cells 1993 (Arthritis, Rheumatoid...) : TNF alpha treatment of human umbilical vein endothelial ( HUVE ) cells induced urokinase-type plasminogen (uPA) activity, increased HUVE uPA dependent extracellular matrix ( ECM ) degradation, and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures