O'Reilly et al., Am J Physiol Cell Physiol 2006
(Anoxia) :
Hypoxia induces epithelial amphiregulin gene expression in a CREB dependent manner
Aguiari et al., J Mol Med (Berl) 2012
(Polycystic Kidney, Autosomal Dominant) :
We now show by microarray analysis, luciferase assay, mutagenesis, and chromatin immunoprecipitation that CREB and AP1 contribute to increased expression of the amphiregulin gene, which codifies for an epidermal growth factor-like peptide, in ADPKD cystic cells, thereby promoting their cell growth