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CREB5 — RELA
Text-mined interactions from Literome
Delfino et al., J Biol Chem 1999
:
Overexpression of
NF-kappaB proteins in primary Sertoli and NIH 3T3 fibroblast cells
induced the
CREB promoter in transient transfection assays ... These data demonstrate that
NF-kappaB contributes to the up-regulation of
CREB expression in Sertoli cells and raises the possibility that NF-kappaB may induce other Sertoli genes required for spermatogenesis
Pise-Masison et al., Mol Cell Biol 2000
:
Analysis of Tax mutants demonstrated that Tax inactivation of p53 function correlates with the ability of Tax to induce
NF-kappaB but not p300 binding or
CREB transactivation
Jeon et al., Immunopharmacology 2000
:
Treatment of DEX to RAW 264.7 cells
induced a dose related inhibition of
NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor
CREB/ATF activation was affected by DEX
Abraham et al., J Immunol 2001
(Endotoxemia...) :
In contrast, alpha-adrenergic blockade before endotoxemia was associated with decreased activation of MEK1/2, ERK2, and
CREB , but
increased activation of
NF-kappa B
Don et al., Mol Cell Endocrinol 2002
:
In addition, TNFalpha secreted by round spermatids, activates
NF-kappaB dependent
CREB expression in Sertoli cells and thus, contributes to the elevated CREB levels as long as these cells are intimately associated
Jaramillo et al., J Immunol 2002
(MAP Kinase Signaling System) :
Similarly, selective inhibition of cAMP and
NF-kappaB strongly
down-regulated the induction of all chemokine transcripts as well as
CREB and NF-kappaB activation, respectively
Mackenzie et al., FASEB J 2004
:
EC, CT, and DP-B
inhibited , in vitro,
NF-kappaB binding to its DNA consensus sequence, but they had no effect on the binding activity of
CREB or OCT-1
Kaltschmidt et al., Mol Cell Biol 2006
(Synaptic Transmission) :
Consequently,
NF-kappaB inhibition
led to a decrease in forskolin induced
CREB phosphorylation
Zuscik et al., Environ Health Perspect 2007
:
Although Pb had no effect on basal
CREB or Wnt/beta-catenin pathway activity, it
induced NFkappaB signaling and inhibited AP-1 signaling
Deree et al., Clinics (Sao Paulo) 2008
(Sepsis) :
The increased level of cAMP that results from phosphodiesterase inhibition affects cytoplasmic and nuclear events, resulting in the attenuation of
NF-kB and the
activation of
CREB transcriptional DNA binding through pathways that are partially Protein kinase A-independent
Yao et al., J Neurosci 2009
:
Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of CCL2 induced
ERK/CREB activation but not
Akt/NF-kappaB activation
Parry et al., J Immunol 1997
:
These results suggest that activation of the protein kinase A pathway
inhibits NF-kappaB transcription by phosphorylating
CREB , which competes with p65 for limiting amounts of CBP