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MAML1 — NOTCH4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
NOTCH4
→
MAML1
(direct_complex)
-
Reactome Reaction:
NOTCH4
→
MAML1
(reaction)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAML1
—
NOTCH4
(direct interaction, pull down)
Wu et al., Nat Genet 2000
-
IRef Hprd Interaction:
MAML1
—
NOTCH4
(in vitro)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2001
-
IRef Hprd Interaction:
MAML1
—
NOTCH4
(in vivo)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2001
-
IRef Hprd Interaction:
MAML1
—
NOTCH4
(two hybrid)
Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2001
Text-mined interactions from Literome
Wu et al., Semin Cancer Biol 2004
(Cell Transformation, Neoplastic) :
Here, we review our current understanding of the
roles of the
MAML proteins in
Notch signaling, and their involvement in certain human cancers
Maillard et al., J Exp Med 2006
:
These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional
activation by
Notch via the
CSL/RBP-J-MAML complex
Köchert et al., Oncogene 2011
(Lymphoma) :
Finally, in line with the essential
role of
MAML proteins for assembly and activity of the
NOTCH transcriptional complex ( NTC ) , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro
Oyama et al., Development 2011
:
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are
essential for
Notch signaling in vivo
Brimer et al., Oncogene 2012
:
Cutaneous papillomavirus E6 oncoproteins associate with
MAML1 to
repress transactivation and
NOTCH signaling
Horn et al., Proc Natl Acad Sci U S A 2012
:
Impeding
Notch mediated transcriptional
activation by conditional expression of dominant negative
Mastermind-like 1 (Maml1) resulted in a similarly distorted P-D patterning and suppressed ß-cell formation, as did conditional inactivation of the Notch target gene Hes1
Zhang et al., Development 2013
(Hyperplasia...) :
Collectively, these findings indicated that
Maml mediated
Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis and homeostasis through regulation of Klf4 and Klf5
Meyers et al., J Virol 2013
:
Cutaneous ß-human papillomavirus ( ß-HPV ) E6 proteins
inhibit NOTCH signaling by associating with the transcriptional coactivator
MAML1