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IL12B — SOCS3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL23-mediated signaling events: SOCS3 (SOCS3) → IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: SOCS3 (SOCS3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Inoue et al., Arerugi 2006 (Asthma...) : SOCS3 controls IL-12 dependent STAT4 activation and Th2 differentiation process
Zhang et al., J Immunol 2008 (Multiple Sclerosis) : Our results demonstrated statin mediated increases in suppressor of cytokine secretion (SOCS) 3 and suppressor of cytokine secretion 7, which negatively regulate the STAT/JAK signal transduction pathway and IL-6 and IL-23 gene expression in monocytes
Ramgolam et al., J Immunol 2009 (Multiple Sclerosis) : We propose that IFN-beta-1a mediated up-regulation of the suppressor of cytokine signaling 3 expression, induced via STAT3 phosphorylation, mediates IL-1beta and IL-23 down-regulation, while IFN-beta-1a induced STAT1 phosphorylation induces IL-27p28 expression
Carow et al., PLoS Pathog 2013 : Instead, SOCS3 expression in infected macrophages and DCs prevented the IL-6 mediated inhibition of TNF and IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo