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IL12B — STAT6

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → STAT6 (STAT6) (modification, activates) Moriggl et al., J Immunol 1998
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: STAT6 — IL12B (interaction, mapped from grid)
• STRING interaction: IL12B — STAT6 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Levings et al., J Immunol 1999 : These data show that STAT6 is required for the IL-4 mediated inhibition of the production of TNF-alpha and IL-12 stimulated by LPS alone, but that IL-4 also activates distinct, STAT6 independent mechanism(s) that inhibit the IFN-gamma mediated enhancement of IL-12 and TNF-alpha production
Fujimoto et al., Int Immunol 2002 : Since IL-12 induced STAT4 and IL-4 induced STAT6 activation is sustained in SOCS-1 ( -/- ) T cells, the enhanced T ( h ) functions in SOCS-1 ( -/- ) and SOCS-1 ( +/- ) mice appear to be due to the enhanced effects of these cytokines
Filén et al., Mol Cell Proteomics 2009 : Besides T cell receptor signaling, IL-12 induced STAT4 and T-bet- and IL-4 induced STAT6 and GATA3 signaling pathways are the major players regulating the Th1 and Th2 differentiation process, respectively
Aerts et al., Clin Exp Rheumatol 2010 (Arthritis, Rheumatoid) : Peripheral blood mononuclear cells ( PBMC ) were analysed flow cytometrically either directly after isolation or after 24 hours of anti-CD3/anti-CD28 stimulation, to determine spontaneous and IL-4/IL-12 induced STAT4 and STAT6 phosphorylation in CD4+ T cells
Huang et al., Mol Biol Rep 2012 : STAT4 and STAT6 were activated by interleukin (IL)-12 and IL-4 stimulation, which were important for the generation of Th1 and Th2 cells
Yin et al., Cancer Lett 2012 (Colonic Neoplasms...) : Mechanistic studies revealed that over-expression of IL-12 reduced the expression of IL-4 and STAT6 in CSCs
Moriggl et al., J Immunol 1998 : In Th1 cells, IL-12 activated both STAT6 and STAT4, and IL-4 activated STAT6 , but in both cases the Th1 phenotype remained