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CASP9 — HMGB1

Text-mined interactions from Literome

Völp et al., Gut 2006 (Colonic Neoplasms) : Finally, we demonstrated that HMGB1 overexpression suppressed caspase-9 and caspase-3 activity, suggesting that HMGB1 interferes with the apoptotic machinery at the level of apoptosomal caspase-9 activation
Ramos et al., J Immunol 2010 (Sepsis) : MC stabilizers fail to inhibit HMGB1 secretion from macrophages, but they prevent apoptosis and caspase-3 activation in sepsis
Lamkanfi et al., J Immunol 2010 (Endotoxemia...) : We found that HMGB1 secretion from LPS primed macrophages required the inflammasome components apoptotic speck protein containing a caspase activation and recruitment domain ( ASC ), caspase 1 and Nalp3, whereas HMGB1 secretion from macrophages infected in vitro with Salmonella typhimurium was dependent on caspase 1 and Ipaf
Gwak et al., World J Gastroenterol 2012 : HMGB1 induced caspase 3 activation was significantly attenuated by the p38 inhibitor SB203580
Kamo et al., Hepatology 2013 (Reperfusion Injury) : Conclusion : ASC mediated caspase-1/IL-1ß signaling promotes HMGB1 to produce a TLR4 dependent inflammatory phenotype and leads to hepatocellular injury
Li et al., Inflamm Res 2013 (Liver Failure) : Furthermore, the hepatic levels of HMGB1, TLR4, caspase3 and P65 were also down-regulated by HMGB1 blockade