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COA4 — FAS
Text-mined interactions from Literome
Pizer et al., Cancer Res 2000
(Breast Neoplasms) :
FAS inhibitors
induced a rapid increase in intracellular
malonyl-CoA to several fold above control levels, whereas TOFA reduced intracellular malonyl-CoA by 60 %
Lane et al., Biochem Soc Trans 2005
:
Inhibitors of
FAS , administered i.c.v. ( intracerebroventricularly ) to lean or obese mice,
cause a rapid rise in hypothalamic
malonyl-CoA level, suppression of food intake, increased fatty acid oxidation in skeletal muscle and profound weight loss
Bandyopadhyay et al., Cancer Res 2006
(Breast Neoplasms) :
Collectively, our results indicate that inhibition of
FAS in breast cancer cells
causes accumulation of
malonyl-CoA , which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3, TRAIL, and DAPK2, resulting in apoptosis
Wolfgang et al., J Biol Chem 2006
(Weight Gain) :
Fatty acid synthase (FAS) inhibitors, administered systemically or intracerebroventricularly to lean or obese mice,
increase hypothalamic
malonyl-CoA leading to the suppression of food intake
Lane et al., Int J Obes Relat Metab Disord 2008
:
Inhibitors of
FAS , administered systemically or intracerebroventricularly to mice,
increase hypothalamic
malony-CoA and suppress food intake
Chen et al., J Food Sci 2011
:
The inhibition kinetic results showed that OCE and
acetyl-CoA competitively
inhibited FAS but these compounds exhibited mixed inhibition against malonyl-CoA and NADPH