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CEACAM5 — IFNG

Text-mined interactions from Literome

Song et al., Gene Ther 2000 (Neoplasms) : As well, CEA/P815 stimulated IFN gamma secretion in vitro was increased, but IL-4 diminished, consistent with a T-helper type 1 ( Th1 ) response ... The latter treatment inhibited CEA/P815 dependent IFN gamma production but enhanced IL-4 secretion, consistent with a Th type 2 ( Th2 ) response
Song et al., Gene Ther 2000 (Neoplasms, Experimental) : CD4-KO and IFNgamma-KO mice still generated CTLs. CEA stimulated IFNgamma production occurred in both CD4- or CD8-KO mice and in both cases was augmented by IL-12
Fahlgren et al., Scand J Immunol 2003 : Additionally, IFN-gamma induced increased cell surface expression of CEA, CEACAM1 and CECAM6
Greiner et al., J Clin Oncol 1992 (Gastrointestinal Neoplasms...) : IFN-gamma administered IP dramatically increased TAG-72 ( as measured by binding of anti-TAG-72 monoclonal antibodies [ MoAbs ] B72.3 and CC 49 ) and CEA ( measured by MoAb COL-1 ) expression on the surface of the carcinoma cells
Sasaki et al., Cancer Sci 2006 (Colorectal Neoplasms) : These T bodies showed high cytotoxicity and produced IFN-gamma in response to CEA expressing autologous tumor cells, even in the presence of soluble CEA
Toth et al., J Interferon Res 1990 (Colorectal Neoplasms) : IFN-alpha and IFN-gamma resulted in increased CEA production ( 2- to 81-fold increase ) primarily in the moderately to well differentiated cell lines ... IFN-gamma was a more potent inducer of enhanced CEA secretion than IFN-alpha
Maas et al., Int J Cancer 1991 (Colonic Neoplasms...) : IFN-gamma was able to enhance the expression of HLA Class I and CEA in 4/7 and 3/7 cell lines, respectively, as measured by flow cytometry
Guadagni et al., Cancer Res 1990 (Colorectal Neoplasms) : Regulation of carcinoembryonic antigen expression in different human colorectal tumor cells by interferon-gamma ... The regulation of carcinoembryonic antigen (CEA) expression by recombinant human interferon-gamma (IFN-gamma) was studied in a series of 7 human colorectal tumor cell lines at various stages of differentiation ... The findings also suggested that the regulation of CEA expression by IFN-gamma is not related to the degree of cellular differentiation and, furthermore, provide some insight into which human tumor cell populations may be the most amenable to tumor antigen augmentation by IFN-gamma in an adjuvant setting with a monoclonal antibody
Klaile et al., Respir Res 2013 (Pulmonary Disease, Chronic Obstructive) : Interferon-gamma also increased CEACAM5 expression
Dansky-Ullmann et al., Cytokine 1995 (Colonic Neoplasms...) : Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells : role for endogenous IFN-beta ... When administered as single agents, both interferon gamma (IFN-gamma) and interleukin 6 (IL-6) significantly increase carcinoembryonic antigen (CEA) and HLA class I antigen expression on the surface of human colorectal tumour cells
Majuri et al., APMIS 1994 (Adenocarcinoma...) : The expression of CEA on cultured endothelial cells can be enhanced by TNF-alpha or IFN-gamma , and decreased by IL-4
Takahashi et al., Cancer Res 1993 (Colonic Neoplasms) : Maximal induction of CEA by IFN-gamma and tumor necrosis factor alpha (TNF-alpha) in the colon carcinoma cell line HT-29 occurs at 5-6 days with maximal secreted levels at 14 ng/ml for IFN-gamma and 20 ng/ml for TNF-alpha
Shimada et al., In Vivo 1993 (Adenocarcinoma...) : The regulation by interferon-gamma (IFN-gamma) of the expression of seven distinct human tumor associated antigens [ M 110,000, carcinoembryonic antigen (CEA) , nonspecific crossreacting antigen (NCA), CA19-9, 17-1A, TAG-72, and D612 ] was studied in eight human gastric cancer cell lines