Wu et al., J Clin Invest 2002
(Myotonia Congenita) :
These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Bode et al., Immunology 2007
:
In contrast, HDAC inhibitors had no effects on upstream nuclear factor-kappaB and mitogen activated protein kinase activation