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Mitra et al., Am J Respir Crit Care Med 2011
(Disease Models, Animal...) :
We sought to define the role of GADD45a in the regulation of Akt activation induced by mechanical stress ... These studies highlight a novel role for GADD45a in the regulation of site-specific Akt ubiquitination and activation and implicate a significant functional role for GADD45a in the clinical predisposition to VILI
Amente et al., Nucleic Acids Res 2011
:
Myc and PI3K/AKT signaling cooperatively repress FOXO3a dependent PUMA and GADD45a gene expression