Gene interactions and pathways from curated databases and text-mining

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AKT1 — MAPK14

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sumitomo et al., Cancer Res 2001 (Prostatic Neoplasms) : Incubation of TSU-Pr1 cells with specific kinase inhibitors together with ET-1 or bombesin showed that IGF-IR activation is required for neuropeptide induced Akt phosphorylation, and that neuropeptide induced Akt activation is predominantly mediated by Src and phosphatidylinositol 3-kinase but not by mitogen activated protein kinase or protein kinase C
Cuello et al., Cancer Res 2001 (Breast Neoplasms...) : Down-regulation of the erbB-2 receptor protein by trastuzumab or antisense oligodeoxynucleotides decreased Akt kinase activation but not mitogen activated protein kinase activation
Delehedde et al., Eur J Biochem 2001 : PD098059 also inhibited the stimulation of Akt phosphorylation by HGF/SF and wortmannin similarly inhibited the stimulation of p42/44(MAPK) dual phosphorylation
Smit et al., J Virol 2002 : Activation of Akt by ORF74 appears to be phosphatidylinositol 3-kinase (PI3-K) dependent but, interestingly, is also mediated by activation of protein kinase C ( PKC ) and p44/p42 MAPK
Kettritz et al., J Am Soc Nephrol 2002 : p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of Akt in response to TNF-alpha and to ANCA
Kawauchi et al., Int J Hematol 2002 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn, Syk, p21ras, JNK, p38 MAPK , or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Trümper et al., J Endocrinol 2002 (MAP Kinase Signaling System) : These interactions included : ( i ) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, ( ii ) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, ( iii ) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and ( iv ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream
Motley et al., Hypertension 2003 : By contrast, an epidermal growth factor receptor inhibitor ( AG1478 ), a p42/44 mitogen activated protein kinase ( MAPK ) kinase inhibitor ( PD 598,059 ), and a p38 MAPK inhibitor ( SB 203,580 ) did not block the Ang II-induced inhibition of Akt phosphorylation
Chien et al., J Lipid Res 2003 : Overexpression of p85-DN or Akt-DN mutants attenuated MEK1/2 and p42/p44 MAPK phosphorylation stimulated by OxLDL and EGF
Garami et al., Mol Cell 2003 : Moreover, Rheb overexpression induces S6K1 phosphorylation and inhibits PKB phosphorylation, as do loss-of-function mutations in TSC1/2, but contrary to earlier reports Rheb has no effect on MAPK phosphorylation
Horowitz et al., J Biol Chem 2004 : Pharmacological inhibition of p38 MAPK with SB203580 or expression of a p38 kinase-deficient mutant protein inhibits TGF-beta1 induced PKB/Akt phosphorylation ... Pharmacological inhibition of p38 MAPK with SB203580 or expression of a p38 kinase-deficient mutant protein inhibits TGF-beta1 induced PKB/Akt phosphorylation
Sandra et al., Oral Oncol 2004 (Ameloblastoma...) : MK could induce phosphorylation of p44/42 MAPK ( Thr202/Tyr204 ) and Akt ( Ser473 and Thr308 ), and by pretreatment of PD98059, MEK1 inhibitor, or LY294002, PI3K inhibitor, MK-stimulated-phosphorylation of MAPK and Akt and MK-stimulated growth of AM-1 cells were inhibited
Taniyama et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells ... Inhibition of p38 MAPK activity with SB-203580 dose-dependently inhibits Akt phosphorylation on Ser ( 473 ), but not Thr ( 308 )
Rieger-Christ et al., Oncogene 2004 (Carcinoma...) : Also, while MAPK and p38 kinase inhibitors did not alter the invasive behavior of these cells, an increase in the phosphorylation of Akt at serine-473 was detected in N-cadherin transfectants, suggestive of N-cadherin mediated Akt activation in bladder cell invasion
Latronico et al., Ann N Y Acad Sci 2004 : In fact, overexpression of AKT does not lead to MAPK activation
Fang et al., J Immunol 2004 (Inflammation) : Results indicated that LPS induced MAPK phosphorylation is enhanced in SHIP ( +/+ ) cells, whereas Akt phosphorylation is enhanced in SHIP ( -/- ) cells compared with SHIP ( +/+ ) cells
Li et al., J Pharmacol Exp Ther 2005 : These data indicate that Ang II-stimulated Akt activity is mediated by cPLA(2) dependent, p38 MAPK regulated PLD(2) activation and EGFR transactivation
Zhang et al., Cancer Res 2005 (Pancreatic Neoplasms) : These changes were accompanied by a concomitant attenuation of activation of mitogen activated protein ( MAP ) kinases , AKT , and NF-kappaB
Auld et al., Biochem J 2005 : CRHSP24 also became phosphorylated at Ser52 in response to EGF ( epidermal growth factor ) and this was prevented by blocking activation of both the classical MAPK cascade and the activation of PKBalpha , but not if just one of these pathways was inhibited
Mizutani et al., Biochim Biophys Acta 2005 : Previous studies also showed that the activation of p38 MAPK by viral infection induced apoptosis, and a weak activation of Akt was not sufficient to protect from apoptosis
Jin et al., Acta Pharmacol Sin 2005 (Brain Diseases) : SF significantly prevented Abeta induced increases in IL-1beta and p38 MAPK activation and also Abeta induced changes in phospho-ERK and phospho-Akt/PKB expression levels ... SF significantly prevented Abeta induced increases in IL-1beta and p38 MAPK activation and also Abeta induced changes in phospho-ERK and phospho-Akt/PKB expression levels
Minelli et al., Peptides 2006 : It greatly enhances the phosphorylation of hsp27, alpha-B-crystallin, Cdc2, and p-38 MAPK , whereas it decreases the phosphorylation of MEK1, Cav 2, GSK3a, PKB/Akt , PKCdelta, PKCgamma, and Erk2 ... It greatly enhances the phosphorylation of hsp27, alpha-B-crystallin, Cdc2, and p-38 MAPK , whereas it decreases the phosphorylation of MEK1, Cav 2, GSK3a, PKB/Akt , PKCdelta, PKCgamma, and Erk2
Vadlamudi et al., Cancer Res 2005 (Breast Neoplasms...) : In addition, PELP1-cyto cells exhibited increased association of PELP1 with Src, enhanced mitogen activated protein kinase ( MAPK ) activation , and constitutive activation of AKT
Venkatesan et al., Cell Signal 2006 : These data provide the first evidence that PI 3 kinase dependent Akt and PKCepsilon activation independently regulate MAPK activity and serine phosphorylation of STAT1alpha to increase expression of MCP-1
Biswas et al., FEBS Lett 2006 (Carcinoma, Hepatocellular...) : CEP triggered the generation of reactive oxygen intermediates, the activation of mitogen activated protein kinase ( MAPK ) p38, JNK1/2 and p44/42, and the downregulation of protein kinase B/Akt ... CEP triggered the generation of reactive oxygen intermediates, the activation of mitogen activated protein kinase ( MAPK ) p38, JNK1/2 and p44/42, and the downregulation of protein kinase B/Akt
Trinidad et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : The effect of coupling C3bi to immunoglobulin G ( IgG ) immune complexes ( IC ) on their ability to produce protein tyrosine phosphorylation and activation of the mitogen activated protein kinase ( MAPK ) and the Akt/protein kinase B (PKB) routes was assessed in human monocytes ... The effect of coupling C3bi to immunoglobulin G ( IgG ) immune complexes ( IC ) on their ability to produce protein tyrosine phosphorylation and activation of the mitogen activated protein kinase ( MAPK ) and the Akt/protein kinase B (PKB) routes was assessed in human monocytes
Xu et al., Am J Physiol Lung Cell Mol Physiol 2006 (Hyperoxia...) : Taken together, these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS, activation of ERK/MAPK , and PI3K-Akt cell survival signaling pathways
Shi et al., Breast Cancer Res Treat 2006 (Breast Neoplasms) : Inhibition of p38 MAPK resulted in decreased phospho-HSP-27 and phospho-Akt , while down-regulation of HSP-27 with a small interfering RNA decreased phosphorylation of Akt, directly linking activation of p38 to Akt
Grethe et al., Biochem Biophys Res Commun 2006 : Notably, we also found that doxorubicin provoked apoptosis included p38 MAPK mediated inhibition of Akt and Bad phosphorylation
Hull et al., J Virol 2006 (Cell Transformation, Viral) : The supertransforming mutants generally showed increased signaling through Akt and reduced activation of p38 MAPK that is inhibitory for transformation
Zhang et al., Biochem Pharmacol 2007 (Prostatic Neoplasms) : In PC-3 cells, CMEP has been found to inhibit only AKT activation at both normal and serum-starvation conditions, not to inhibit PI3K, PDK1, or MAPK
Punn et al., Mol Endocrinol 2006 : UCN I effect on p38 MAPK phosphorylation was more transient, returned to basal within 40 min and was dependent on epidermoid growth factor receptor transactivation, but not PI3-K/Akt activation
Lee et al., Acta Pharmacol Sin 2006 : In terms of SPC induced signaling events, mitogen activated protein kinase activation and Akt activation in iDC and mDC were stimulated
Ziv et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Unlike hSef-b, however, the growth arrest was mediated via a MAPK independent mechanism, and was accompanied by elevated p38 MAPK phosphorylation and inhibition of protein kinase B/Akt ... Unlike hSef-b, however, the growth arrest was mediated via a MAPK independent mechanism, and was accompanied by elevated p38 MAPK phosphorylation and inhibition of protein kinase B/Akt
Chen et al., Biochem Pharmacol 2007 (Lung Neoplasms) : Tangeretin suppresses IL-1beta induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK , JNK, and AKT activation in human lung carcinoma cells
Horowitz et al., Cell Signal 2007 : Here, we demonstrate that FAK and AKT are independently regulated by early activation of SMAD3 and p38 MAPK , respectively
Tong et al., J Neurochem 2007 (Meningioma) : Midkine stimulation of cultured meningioma cells induced phosphorylation of Akt , whereas no increase in phosphorylation of p42/44 MAPK or p38 MAPK could be detected
Rajput et al., Cancer Res 2007 (Colonic Neoplasms...) : The reversal of constitutive EGFR activation results in the loss of downstream mitogen activated protein kinase and Akt activation , and a reduction in xenograft size that is associated with decreased proliferation and increased apoptosis
Chuang et al., Endocrinology 2007 (Diabetes Mellitus, Experimental...) : MAPK/ERK inhibitor PD98059 inhibited the PI3K activity, Akt phosphorylation, and lipid accumulation triggered by HG
Diehl et al., J Surg Res 2007 (Breast Neoplasms...) : We also found that AKT was activated by p38MAPK in these cells, but this activation did not play a role in invasion ... We found that, in the absence of EGF, p38MAPK activated AKT is necessary for HER-2 overexpressing cells to survive and to form colonies in soft agar ... We show that EGF works as a survival signal in the absence of p38MAPK mediated activation of AKT
Nguyen et al., J Biochem Mol Biol 2007 (MAP Kinase Signaling System) : Here, we report that the enzymatic activity of phospholipase C-gamma1 ( PLC-gamma1 ) is at least partially involved to the blockage of neuronal differentiation via an abrogation of MAPK activation, as well as sustained Akt activation
Zheng et al., J Neurochem 2008 (Ion Channel Gating) : Although previous studies suggested the roles of mitogen activated protein kinase , phospholipase C-gamma mediated intracellular calcium ( [ Ca2+ ] i ) increase, and extracellular calcium influx in regulating Akt activation, the cellular mechanisms are largely unknown ... The TrkB dependent Akt phosphorylation at S473 and T308 required only phosphoinositide 3-kinase, but not phospholipase C and mitogen activated protein kinase activity
Kim et al., Stem Cells 2008 : Furthermore, mitogen activated protein kinase 1/2 inhibitor or knockdown of Erk1 could restore activation of Akt and downregulate mTOR
Abair et al., Blood 2008 (Neovascularization, Pathologic) : Integrin alpha1beta1 dependent endothelial cell proliferation is primarily mediated by ERK activation, whereas migration and tubulogenesis require both p38 MAPK and PI3K/Akt activation
Kang et al., Eur J Pharmacol 2008 : The LPS induced phosphorylation of p38 MAPK and extracellular signal regulated kinase 1/2 ( ERK1/2 ) was inhibited by PA, but not the phosphorylation of JNK 1/2 and AKT ( Ser473 )
Lemoine et al., Anesthesiology 2008 : In vitro, desflurane postconditioned human atrial myocardium through protein kinase C activation, opening of mitochondrial adenosine triphosphate-sensitive potassium channels, Akt and extracellular regulated kinase 1/2 activation , and p38 mitogen activated protein kinase phosphorylation
Gayer et al., J Biol Chem 2009 : Strain MAPK activation required PI3K but not AKT
Wang et al., Eur J Cell Biol 2009 (Leukemia...) : Ectopic overexpression of Akt inhibited MAPK signaling, downregulated cyclin dependent kinase (CDK) inhibitors p21 ( Wip1/Cip1 ) and p27 ( Kip1 ) and blunted differentiation in response to vitamin D3 while knockdown of Akt by RNA interference gave reverse effects
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : c-Src-p38 mitogen activated protein kinase signaling is required for Akt activation in response to ionizing radiation ... Interestingly, inhibition of p38 MAPK completely attenuated radiation induced Ser ( 473 ) phosphorylation of Akt but did not affect Thr ( 308 ) phosphorylation ... Conversely, overexpression of p38 MAPK enhanced Ser ( 473 ) phosphorylation of Akt in response to radiation
Kim et al., J Cell Physiol 2009 (Calcium Signaling...) : In conclusion, NECA stimulated IL-6 expression via MAPK and NF-kappaB activation through Akt , Ca ( 2+ ) /PKC, and cAMP signaling pathways in mouse ES cells
Ottonello et al., Br J Pharmacol 2009 : The activity of oxaprozin was related to inhibition of Akt activation that, in turn, prevented p38 MAPK , IKK and NF-kappaB activation
Iwai et al., Hypertens Res 2009 : Several factors such as Akt phosphorylation, protein kinase C activation and mitogen activated protein ( MAP ) kinase inhibition seem to be involved in this signaling pathway
Rane et al., American journal of physiology. Renal physiology 2010 (Diabetes Mellitus, Experimental...) : These results collectively suggest that downregulation of Akt activation during long-term hyperglycemia contributes to enhanced p38 MAPK activation and RPTC apoptosis
Widenmaier et al., J Biol Chem 2009 : Using selective enzyme inhibitors, overexpression of dominant negative Akt, and Akt siRNA, it was demonstrated that GIP promoted beta-cell survival via Akt dependent suppression of p38 MAPK and JNK and that combined inhibition was sufficient to explain the entire pro-survival responses to GIP during STS treatment
Pan et al., Chem Res Toxicol 2010 : Silencing Akt by siRNA reduced the activation of ASK1 and p38 MAPK and cell apoptosis, whereas without nickel stimulation, siRNA Akt had no effect on the activation of ASK1 and p38 MAPK
Kozono et al., Biochem Biophys Res Commun 2010 : CP55940 ( CB1/CB2 agonist ) induced phosphorylation of the extracellular regulated kinases (ERK) 1/2, p38 mitogen activated protein kinase ( p38MAPK ), and Akt in HGFs. Wound closure by CP55940 in an in-vitro scratch assay was significantly suppressed by inhibitors of MAP kinase kinase ( MEK ), p38MAPK , and phosphoinositol 3-kinase (PI3-K)
Grotegut et al., Int J Oncol 2010 (Hepatoblastoma...) : Here, we demonstrate that HGF has no impact on overall cell viability and proliferation of HB cells, although signal transduction occurs downstream of HGF, such as c-Met phosphorylation, activation of phosphoinositide 3-kinase (PI3K)/AKT and mitogen activated protein kinase ( MAPK ) /ERK-1/2 signaling
Bocelli-Tyndall et al., Arthritis Rheum 2010 : Both MAPK/ERK-1/2 and phosphatidylinositol 3-kinase/Akt controlled cell proliferation and HLA-DR expression, but only MAPK/ERK-1/2 controlled the induction of the class II MHC transcription activator protein CIITA, the major determinant of HLA-DR transcription
Basuroy et al., Am J Physiol Cell Physiol 2011 : The ability of CO to inhibit TNF-a induced ERK1/2 and p38 MAPK activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease
Yin et al., J Mol Med (Berl) 2011 (Disease Models, Animal...) : Our results demonstrated that administration of Rg1 increased VEGF expression levels, activated PI3K/Akt , and inhibited p38 MAPK in vitro and in vivo ... Rg1 induced activation of PI3K/Akt also contributed to the downregulation of p38 MAPK
Lasala et al., Am J Physiol Endocrinol Metab 2011 : Blocking PKA abolished the effect of cAMP on Sox9, Sf1, and Gata4 expression, inhibiting PI3K/PKB impaired the effect on Sf1 and Gata4, and reducing MEK1/2 and p38 MAPK activities curtailed Gata4 increase
Horan et al., Invest New Drugs 2012 (Endometrial Neoplasms) : In addition, cells attempted to counteract drug treatment by pro-survival signaling such as deactivation of JNK/SAPK and p38 MAPK and activation of AKT and ErK1/2
Lei et al., Am J Physiol Lung Cell Mol Physiol 2011 : In the present study, we assessed the role of Akt in Na-K-ATPase activity and the interaction between the PI3K and MAPK in response to T3 by using MP48 cells, inhibitors, and constitutively active mutants in the MP48 ( alveolar type II-like ) cell line
Buitrago et al., J Cell Biochem 2012 : The involvement of p38 MAPK in Akt phosphorylation by the hormone probably occurs through MAPK activated protein kinase 2 (MK2), which is activated by the steroid
Peart et al., Rejuvenation Res 2012 (Ischemia...) : CR counters age effects on postischemic dysfunction/cell death ; this is associated with reversal of age effects on p70S6K, augmentation of Akt and Bcl2 levels, and preischemic p38-MAPK activation
Sousa et al., Proc Natl Acad Sci U S A 2012 : These experiments demonstrate that dynamin mediated endocytosis leads to attenuation of EGFR activation and degradation and that stimulation of the MAPK response and Akt activation are primarily mediated by activated EGFR located in the plasma membrane
Huang et al., J Cell Biochem 2012 : Inhibition of calcineurin further reduced the phosphorylation of ERK and AKT ( at thr 308 ) and inhibited the activation of Ras, but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity
Yang et al., J Mol Med (Berl) 2013 (Endotoxemia...) : LPS caused p38 MAPK- , JNK-, and PI3K/AKT mediated Mcl-1 stabilization and prevented apoptosis, and LPS induced GSK-3ß inactivation mainly through p38 MAPK and PI3K/AKT
Choi et al., J Cell Physiol 2013 (Neoplasms) : Furthermore, whereas Compound C ( an AMPK inhibitor ), AMPK-DN ( AMPK-dominant negative ) mutant, and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , TCN ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA inhibited the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 MAPK ... Furthermore, whereas Compound C ( an AMPK inhibitor ), AMPK-DN ( AMPK-dominant negative ) mutant, and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , TCN ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA inhibited the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 MAPK
Jayakumar et al., J Nutr Biochem 2013 : Furthermore, a PI3-kinase inhibitor ( LY294002 ) and a p38 MAPK inhibitor ( SB203580 ) both significantly diminished PKC activation and p38 MAPK and Akt phosphorylation ; in contrast, a PKC inhibitor ( RO318220 ) did not diminish p38 MAPK or Akt phosphorylation stimulated by collagen
Su et al., J Cell Mol Med 2013 (Hyperglycemia...) : In addition, HG activated p38 MAPK and inhibited Akt in I/R hearts ... Moreover, inhibition of p38 MAPK or activation of Akt markedly blocked HG-induced Txnip expression in I/R cardiomyocytes
Pan et al., Evidence-based complementary and alternative medicine : eCAM 2012 : In addition, Tan IIA mediated translocation of C-Raf which interacted with prohibitin activating MAPK and inhibiting AKT signaling in HSC
Aslan et al., Arterioscler Thromb Vasc Biol 2013 : Stimulation of platelets with the glycoprotein receptor VI agonist, collagen related peptide, rapidly activated PAK in a time course preceding phosphorylation of PAK substrates, LIM domain kinase LIMK1 and the MAPK/ERK kinase MEK, and the subsequent activation of MAPKs and Akt
Zhang et al., J Cardiovasc Pharmacol 2013 (Constriction, Pathologic...) : Ginsenoside Rg1 exhibited protective effect against TAC induced left ventricular hypertrophy and cardiac dysfunction, which is potentially associated with phospho-Akt activation and p38 MAPK inhibition
Deprez et al., J Biol Chem 1997 : All the protein kinases phosphorylated Ser-466 and Ser-483 in the BH1 isoform, but to different extents : p70 ( s6k ) preferentially phosphorylated Ser-466, whereas mitogen activated protein kinase activated protein kinase-1 and PKB phosphorylated Ser-466 and Ser-483 to a similar extent
Cuenda et al., J Biol Chem 1999 : The differentiation of C2C12 myoblasts to myotubes was found to be accompanied by a strong activation of p70 S6 kinase and the mitogen activated protein kinase ( MAPK ) family member SAPK2/p38, without significant activation of p42 MAPK and only slight activation of SAPK1/JNK and protein kinase Balpha