◀ Back to EGFR

CHMP2B — EGFR

Text-mined interactions from Literome

Langelier et al., J Virol 2006 : Consistent with its expected role in MVB vesicle formation, ( i ) human ESCRT-II localized to endosomal membranes in a VPS4 dependent fashion and ( ii ) depletion of EAP20/ESCRT-II and CHMP6/ESCRT-III inhibited lysosomal targeting and downregulation of the epidermal growth factor receptor , albeit to a lesser extent than depletion of TSG101/ESCRT-I
Malerød et al., Traffic 2007 : Depletion of Vps22 by small interfering RNA, which was accompanied by decreased levels of other ESCRT-II subunits, greatly reduced degradation of EGFR and its ligand EGF as well as the chemokine receptor CXCR4 ... These results indicate an important role for Vps22 in ligand induced EGFR and CXCR4 turnover and suggest that termination of EGF signaling occurs prior to ESCRT-II engagement