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EGFR — PDGFRB
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Stacchiotti et al., Clin Cancer Res 2009
(Sarcoma, Alveolar Soft Part) :
The role of MET,
epidermal growth factor receptor , and mTOR, as well as
PDGFR inhibition , needs to be further explored
Abouantoun et al., Mol Cancer Ther 2009
(Medulloblastoma...) :
Imatinib treatment also induced DAOY cell apoptosis at 72 h and inhibited DAOY and D556 cell proliferation at 48 h. siRNA silencing of
PDGFRB similarly inhibited signaling, migration, and survival and both siRNA and imatinib treatment
inhibited PDGF-BB mediated
EGFR transactivation, indicating that the effects of imatinib treatment are specific to PDGFRB target inhibition
Brennan et al., PloS one 2009
(Brain Neoplasms...) :
In the pattern of signaling, three subclasses of GBM emerge which appear to be associated with predominance of
EGFR activation,
PDGFR activation , or loss of the RAS regulator NF1
Descorbeth et al., J Mol Cell Cardiol 2010
:
Pre-treatment of A10 VSMC with high glucose ( 26 mM ) for 3 days, increased the levels of Gqalpha, G11alpha, PLCbeta-1 and PLCbeta-2 proteins which were restored to control levels by AG1478, an inhibitor of
EGF-R , AG1295, an
inhibitor of
PDGF-R and PP2, an inhibitor of c-Src but not by PP3
Yi et al., Otol Neurotol 2012
(Neuroma, Acoustic) :
Activation of both
EGFR and PDGFR resulted in increase in the induction of the expression of the stem cell genes Oct-4 and Nanog and marked increase in tumorsphere forming ability, but only
PDGFR activation
resulted in an increase in the side population in JS1 cells