Gene interactions and pathways from curated databases and text-mining

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CDKN1B — HRAS

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CDKN1B → HRAS (decreases, CDKN1B Activity) Yoo et al., Int J Oncol 2006*
    Evidence: H-RasG12V expression down-regulated p27Kip1 expression, and that RASSF1A co-transfected with H-RasG12V recovered p27Kip1 expression that had been down-regulated by H-RasG12V expression. Similarly, p21WAF1/CIP1 was induced by H-RasG12V expression and RASSF1A co-transfected with H-RasG12V inhibited p21WAF1/CIP1 induction.