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GRB2 — IL3

Pathways - manually collected, often from reviews:

• BioCarta il 3 signaling pathway: IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: GRB2 → IL3 (reaction) Harmer et al., J Biol Chem 1999, Rozakis-Adcock et al., Nature 1992, Ravichandran et al., J Biol Chem 1994, Odai et al., Blood 1997
• Reactome Reaction: GRB2 → IL3 (indirect_complex) Harmer et al., J Biol Chem 1999, Rozakis-Adcock et al., Nature 1992, Ravichandran et al., J Biol Chem 1994, Odai et al., Blood 1997

Text-mined interactions from Literome

Bratke et al., Clin Exp Allergy 2010 (Inflammation) : Granzyme B (GrB), but not the granzymes A, H, K, M or perforin, was specifically expressed by human pDCs and this GrB expression was up-regulated by IL-3 stimulation
Lee et al., Phytother Res 2013 (Inflammation) : GRb1 significantly reduced the upregulation of tumor necrosis factor-a, interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection
Welham et al., J Biol Chem 1994 : Interleukin (IL)-3 and granulocyte/macrophage colony stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase
Liu et al., Mol Cell Biol 1994 : We recently reported that interleukin-3 , Steel factor, and erythropoietin all induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cell lines