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INS — ME1

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Barroso et al., J Biol Chem 1999 : In this report we have studied insulin regulation of malic enzyme ( ME ) gene transcription in rat H-35 hepatoma cells and localized the insulin-responsive region of the ME promoter between positions -177 and -102
Gletsu et al., J Nutr 1999 : These results suggest that nuclear insulin receptors induce malic enzyme gene expression by regulating phosphorylation of IRE transcription factors
Iizuka et al., Biochim Biophys Acta 2002 : The malic enzyme inhibitor alone inhibited insulin response to glucose
Fukuda et al., J Biochem 1992 : Triiodothyronine markedly enhanced malic enzyme mRNA induction by insulin with dexamethasone, and tended to enhance the induction of the acetyl-CoA carboxylase and fatty acid synthase mRNAs, but not that of glucose 6-phosphate dehydrogenase mRNA
Pongratz et al., J Biol Chem 2007 : Selective reduction ( 89 +/- 2 % ) of cytosolic ME1 mRNA expression and enzyme activity significantly reduced glucose ( 15 mM : 41 +/- 6 %, p < 0.01 ) and amino acid ( 4 mM glutamine +/- 10 mM leucine : 39 +/- 6 %, p < 0.01 ) -stimulated insulin secretion
Matzen et al., Thyroidology / A.P.R.I.M 1991 : The T3 modulation of nuclear T3 binding ( NBT3 ), the T3 effect on cell growth, and the T3 and insulin effects on malic enzyme ( ME ) , glucose-6-phosphat-dehydrogenase (G6PD) and 6-phosphogluconat-dehydrogenase ( G6PD ) were studied in a human hepatocyte cell-line ( Chang-liver )
Valverde et al., Eur J Biochem 1992 : Insulin increased malic-enzyme and Glc6P dehydrogenase expression at the mRNA and protein level after 6 d and 10 d of culture
Guay et al., J Biol Chem 2007 : A role for ATP-citrate lyase, malic enzyme , and pyruvate/citrate cycling in glucose induced insulin secretion
Heart et al., Am J Physiol Endocrinol Metab 2009 : Role for malic enzyme , pyruvate carboxylation, and mitochondrial malate import in glucose stimulated insulin secretion
Pongratz et al., Methods Enzymol 2009 (Insulinoma) : Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion
Brown et al., J Biol Chem 2009 (Insulinoma) : Chronic reduction of the cytosolic or mitochondrial NAD ( P ) -malic enzyme does not affect insulin secretion in a rat insulinoma cell line
Ortiz-Caro et al., Acta Endocrinol (Copenh) 1991 (Diabetes Mellitus, Experimental...) : Triiodothyronine and insulin effects on malic enzyme in hypothyroid and diabetic rats ... We examined the effects of T3 and insulin on the activity of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and cytosolic malic enzyme in control, thyroidectomized, thyroidectomized food restricted, and thyroidectomized diabetic rats ... Insulin failed to stimulate the alpha-glycerophosphate dehydrogenase levels in untreated and T3-treated thyroidectomized groups, but caused an increase in malic enzyme activity by 79-130 % in untreated thyroidectomized groups, and enhanced the activity of this enzyme to about twice that seen with T3 alone ... The data suggest that insulin may act on malic enzyme synthesis through its general stimulatory effect on protein synthesis, or by antagonizing factors that inhibit the induction of this enzyme
Katsurada et al., Biochim Biophys Acta 1989 (Diabetes Mellitus, Experimental) : Effects of insulin and fructose on transcriptional and post-transcriptional regulation of malic enzyme synthesis in diabetic rat liver
McHugh et al., Mol Cell Endocrinol 1989 (Diabetes Mellitus, Experimental) : Prior studies in our laboratory had characterized the insulin mediated increases in hepatic malic enzyme activity in normal and diabetic rats ( Drake et al., 1983 ; Drake and Mucenski, 1985 )
Lorenzo et al., Biochem Biophys Res Commun 1989 : Insulin increased malic enzyme activity and protein content in foetal brown adipocyte primary cultures through a two fold increase in the rates of enzyme synthesis
Davis et al., Biochem Biophys Res Commun 1988 (Diabetes Mellitus, Experimental) : Insulin mediated post-transcriptional regulation of hepatic malic enzyme and albumin mRNAs
Drake et al., Anat Rec 1988 (Diabetes Mellitus, Experimental) : After this point, excessive insulin levels do inhibit malic enzyme activity
Kasturi et al., Arch Biochem Biophys 1984 : Colchicine, however, had no effect on the general protein synthesis, nor did it affect the malic enzyme , which is induced by triiodothyronine but not by insulin
Goodridge et al., Arch Biochem Biophys 1984 : Insulin , another physiologically important regulator of malic enzyme activity in vivo, had no effect on the initial rate of accumulation of malic enzyme activity in the differentiating cells and caused a 30 to 40 % decrease in the final level of enzyme activity in the fully differentiated cells
Katsurada et al., Biochem Biophys Res Commun 1983 (Diabetes Mellitus, Experimental) : Induction of rat liver malic enzyme messenger RNA activity by insulin and by fructose
Yoshimoto et al., J Biol Chem 1983 : In contrast, the induction of malic enzyme ( EC 1.1.1.40, L-malate : NADP+ ) oxidoreductase ) by insulin plus triiodothyronine was strongly suppressed by the concomitant addition of EGF
Rao et al., Horm Metab Res Suppl 1984 : Insulin ( final concentration 0.7 I. U./ml ) alone stimulated malic enzyme activity minimally, but together with triiodothyronine stimulation was additive
Thompson et al., Biochim Biophys Acta 1982 (Body Weight...) : Therefore, the coupling of these two regulatory mechanisms was responsible for the insulin mediated increase in malic enzyme activity
Thompson et al., Mol Cell Endocrinol 1982 (Diabetes Mellitus, Experimental) : Induction of hepatic malic enzyme in response to insulin ... These results demonstrate that the insulin mediated increase in malic enzyme activity was due to an increase in the quantity of enzyme and did not involve a modification of existing enzyme molecules
Guerra et al., Biochem Biophys Res Commun 1994 : However, insulin but not IGF-I induced the expression of the lipogenic marker malic enzyme , suggesting that IGF-I but not insulin is involved in the thermogenic differentiation process of fetal brown adipocytes
Oda et al., Biosci Biotechnol Biochem 1997 : The induction of malic enzyme gene expression by triiodothyronine and insulin was severely blunted in rat monolayer hepatocytes cultured on type I collagen compared with that in spherical hepatocytes cultured on a reconstituted basement membrane gel ( EHS-gel )
Streeper et al., Mol Endocrinol 1998 (Liver Neoplasms, Experimental) : A phorbol ester-insensitive AP-1 motif mediates the stimulatory effect of insulin on rat malic enzyme gene transcription