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MAPK14 — MYC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Whitwam et al., Oncogene 2007
(Cell Transformation, Neoplastic...) :
Although both NRAS and KRAS activate
mitogen activated protein kinase signaling, only NRAS
enhances MYC activity in these cells
Duan et al., Dig Dis Sci 2010
(Bile Duct Neoplasms...) :
Our results revealed that the specific
MAPK-ERK cascade inhibitor, PD98059, significantly
attenuated phosphorylation of
c-Myc on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells
Gramling et al., Cell Death Differ 2012
(Cell Transformation, Neoplastic...) :
We report the novel findings that
Myc alone
induced Ras/Mapk pathway signaling, and increased signaling following growth factor stimulation