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CTD — MED1
Text-mined interactions from Literome
Guidi et al., J Biol Chem 2004
:
Mediator , a global transcriptional co-activator, dramatically
enhances the phosphorylation of the
CTD of RNA pol II by holo-TFIIH in vitro ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that
Mediator enhances phosphorylation of a glutathione
S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase
Jang et al., Mol Cell 2005
:
An increase in
Brd4 expression
led to increased P-TEFb dependent phosphorylation of RNA polymerase II (RNAPII)
CTD and stimulation of transcription from promoters in vivo