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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MED1

MED1 — MED4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., Mol Cell Biol 1999 : The Mediator complex of Saccharomyces cerevisiae is required for both general and regulated transcription of RNA polymerase II (PolII) and is composed of two stable subcomplexes ( Srb4 and Rgr1 subcomplexes )
Strukova et al., Biochemistry (Mosc) 1999 (Inflammation) : TRAP-6 inhibited PAF release from A23187 activated RPMC via an NO-dependent mechanism
Ekhterae et al., Circ Res 1999 : Loss of endogenous ARC in the cytosol of H9c2 cells was associated with translocation of ARC from the cytosol to intracellular membranes, release of cytochrome c from the mitochondria, activation of caspase-3 , poly ( ADP-ribose ) polymerase ( PARP ) cleavage, and DNA fragmentation
Hoshi et al., J Biol Chem 2000 : NF-kappaB was activated after the stimulation of TRAP, bFGF, and TNF-alpha in electrophoretic mobility shift assay, and E5510 suppressed the NF-kappaB activation induced by TRAP and bFGF but not the activation by TNF-alpha ... NF-kappaB was activated after the stimulation of TRAP, bFGF, and TNF-alpha in electrophoretic mobility shift assay, and E5510 suppressed the NF-kappaB activation induced by TRAP and bFGF but not the activation by TNF-alpha ... The phosphorylation of ERK1/2 was rapidly induced by TRAP and bFGF but not by TNF-alpha ... These results indicate that TRAP and bFGF induced I-kappaB degradation and NF-kappaB activation through a distinct pathway from TNF-alpha and that ERK1/2 may play an important role in NF-kappaB activation induced by TRAP and bFGF
Spåhr et al., J Biol Chem 2000 : This stimulation was species-specific, because S. pombe Mediator could not stimulate TFIIH purified from S. cerevisiae
Ohmori et al., Biochemistry 2000 : While BAPTA-AM ( an intracellular Ca2+ chelator ) inhibited Cas phosphorylation induced by collagen or TRAP , Ro31-8220 ( a PKC inhibitor ) rather prolonged it
Guzowski et al., J Neurosci 2001 : Arc RNA expression differed from that of zif268 and c-fos in two regards : ( 1 ) hippocampal Arc RNA levels were correlated with learning of the hippocampal dependent spatial, but not hippocampal independent cued response, water task, and ( 2 ) Arc RNA levels in the hippocampus and entorhinal cortex increased after spatial reversal learning relative to an asymptotic performance group
Kimura et al., Planta Med 2001 : Intercellular adhesion molecule-1 ( ICAM-1 ) expression was also induced by thrombin, but not by TRAP
Waltereit et al., J Neurosci 2001 : Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen activated protein kinase/extracellular regulated kinase activation ... Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen activated protein kinase/extracellular regulated kinase activation
Weber et al., Blood 2001 : ADP induced fibrinogen binding was completely inhibited by 10 microg/mL abciximab, 30 nM tirofiban, or 3 microg/mL eptifibatide, while fibrinogen binding induced by 100 microM TRAP was inhibited only by 50 %
de Rossi et al., Anesth Analg 2001 : In contrast, halothane reduced TRAP-6 induced activation of the GPIIb/IIIa complex
Mittler et al., EMBO Rep 2001 : Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
Huang et al., Zhonghua Xue Ye Xue Za Zhi 1999 : The expression of GPIb was reduced while the expressions of GPIIb/IIIa , IIIa, P-selectin increased after the platelets were activated by TRAP
Sakai et al., J Biochem 2001 : Receptor activator of NF-kappaB ( RANKL ) significantly increased the LBC levels of cathepsin K, TRAP , and c-Src, whereas calcitonin decreased the LBC levels of cathepsin K, TRAP, and Rab7, indicating that the transformation of early to late endosomal elements and lysosomes in OCLs is also regulated by osteoclastogenesis regulatory factors
Elmquist et al., Physiol Behav 2001 (Body Weight) : We found that leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral arcuate nucleus (Arc) that innervate the sympathetic preganglionic neurons in the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )
Kremerskothen et al., Neurosci Lett 2002 (Neuroblastoma) : Insulin induced expression of the activity regulated cytoskeleton associated gene ( ARC ) in human neuroblastoma cells requires p21(ras) , mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent ... Insulin induced expression of the activity regulated cytoskeleton associated gene ( ARC ) in human neuroblastoma cells requires p21(ras), mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Ying et al., J Neurosci 2002 : Brain derived neurotrophic factor induces long-term potentiation in intact adult hippocampus : requirement for ERK activation coupled to CREB and upregulation of Arc synthesis
Espinola et al., Thromb Haemost 2002 : TRAP increased the expression of GPIIb/IIIa and GPIIIa on platelet surface ... TRAP increased the expression of GPIIb/IIIa and GPIIIa on platelet surface
Wang et al., J Biol Chem 2002 : Mediator role of platelet derived growth factor and ERK
Delerive et al., Mol Endocrinol 2002 : By contrast, DRIP205 is not involved in PPARalpha mediated NF-kappaB transcriptional repression
Wang et al., J Virol 2002 (Cell Transformation, Viral) : Much of the large E1A bound to Mediator in 293 cells is in a stable complex that includes RNA polymerase II, leading us to suggest that the interaction of E1A-CR3 with Mediator stabilizes the interaction of Mediator with the polymerase
Shui et al., Calcif Tissue Int 2002 : The combination of rapamycin ( 10 ng/ml ) and TGF-beta1 ( 1 ng/ml ) increased TRAP+MNC 3.1- and 6.9-fold as compared with rapamycin or TGF-beta1 alone, respectively, and enhanced CTR mRNA expression induced by TGF-beta1 by 1.9-fold
Wang et al., J Biol Chem 2002 (Prostatic Neoplasms) : A coregulatory role for the TRAP-mediator complex in androgen receptor mediated gene expression
Sheu et al., J Biol Chem 2003 : Moreover, we show that TRAP interacts with TRIP intracellularly, that activation of the TGFbeta type II receptor by TRIP-1 occurs in the presence of TRAP and that the differentiation process is mediated through the Smad2/3 pathway ... Moreover, we show that TRAP interacts with TRIP intracellularly, that activation of the TGFbeta type II receptor by TRIP-1 occurs in the presence of TRAP and that the differentiation process is mediated through the Smad2/3 pathway
Proulx et al., Endocrinology 2002 (Weight Gain) : In the arcuate nucleus (ARC) , acute leptin increased SOCS-3 and POMC mRNA levels, but decreased NPY mRNA levels in the rostral part of ARC
Acevedo et al., Mol Cell Biol 2003 : We have used a biochemical approach, including an in vitro chromatin assembly and transcription system, to examine the functional role for Mediator in the transcriptional activity of estrogen receptor alpha (ERalpha) with chromatin templates, as well as functional interplay between Mediator and p300/CBP during ERalpha dependent transcription ... Using three different approaches to functionally inactivate Mediator ( immunoneutralization, immunodepletion, and inhibitory polypeptides ), we find that Mediator is required for maximal transcriptional activation by ligand activated ERalpha
Billheimer et al., Thromb Res 2002 (Thrombosis) : All four fibans inhibited ADP and TRAP stimulated fibrinogen binding and microaggregate formation in a concentration dependent manner, whereas P-selectin expression was relatively unaltered
Liu et al., J Biol Chem 2003 : Moreover, the binding is significantly enhanced in EMSA with nuclear extracts from RANKL treated RAW264.7 cells and BMMs, suggesting that the 12-bp sequence may be involved in RANKL induced TRAP transcription ... Importantly, mutation of the USF binding site partially blocks RANKL induced TRAP transcription in RAW264.7 cells, confirming that USF1 and USF2 are functionally involved in RANKL induced TRAP transcription ... Importantly, mutation of the USF binding site partially blocks RANKL induced TRAP transcription in RAW264.7 cells, confirming that USF1 and USF2 are functionally involved in RANKL induced TRAP transcription ... Importantly, mutation of the USF binding site partially blocks RANKL induced TRAP transcription in RAW264.7 cells, confirming that USF1 and USF2 are functionally involved in RANKL induced TRAP transcription
Kumpawat et al., Mutat Res 2003 (Chromosome Aberrations) : The present data indicate that the generation of ROS by ARC could partially contribute to the induction of chromosomal aberrations (CAs), since the frequency of ARC induced CAs was reduced either by post-treatment with superoxide dismutase ( SOD ) or in anoxic conditions
Zakharova et al., J Biol Chem 2003 : Furthermore, in a system with purified proteins and naked DNA, STAT1alpha- and STAT1beta dependent transcription is stimulated by the TRAP/Mediator co-activator complex ... Furthermore, in a system with purified proteins and naked DNA, STAT1alpha- and STAT1beta dependent transcription is stimulated by the TRAP/Mediator co-activator complex ... Furthermore, in a system with purified proteins and naked DNA, STAT1alpha- and STAT1beta dependent transcription is stimulated by the TRAP/Mediator co-activator complex ... Furthermore, in a system with purified proteins and naked DNA, STAT1alpha- and STAT1beta dependent transcription is stimulated by the TRAP/Mediator co-activator complex
Reiter et al., Thromb Haemost 2003 (Endotoxemia...) : PAR1 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly, TRAP induced P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h ... PAR1 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly, TRAP induced P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h
Malabu et al., Peptides 1992 (Body Weight) : We tested the hypothesis that low plasma insulin levels stimulate ARC levels of NPY in fasted rats
Fujimoto et al., J Neurosci Res 2004 (Seizures) : Arc interacts with microtubules/microtubule associated protein 2 and attenuates microtubule associated protein 2 immunoreactivity in the dendrites ... We found that the overexpression of Arc as well as Arc induction by seizure in vivo decreased microtubule associated protein 2 (MAP2) staining in the dendrites by immunocytochemistry, although MAP2 content was not changed on Western blot
Guidi et al., J Biol Chem 2004 : Mediator , a global transcriptional co-activator, dramatically enhances the phosphorylation of the CTD of RNA pol II by holo-TFIIH in vitro ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that Mediator enhances phosphorylation of a glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase ... Using purified proteins we have determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that Mediator enhances phosphorylation of a glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase
Sato et al., Mol Cell 2004 : The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors ... The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors
Pineda Torra et al., J Biol Chem 2004 : Requirement for the FXR/RXR heterodimer in the DRIP205-FXR interaction was evaluated using an RXR heterodimerization-deficient FXR mutant ( FXRL433R )
Wang et al., Genetics 2004 : The rgr1 and sin4 constitutive phenotype does not require either the MAL-activator or maltose permease, indicating that Mediator represses MAL basal expression ... The role of the Mediator in MAL gene regulation is discussed
Shi et al., Gene 2004 : Functionally, mutation of the YY1 binding site resulted in a reduction in the RANKL induced TRAP transcription in RAW264.7 cells, demonstrating that YY1 positively regulates RANKL induced TRAP transcriptional activation ... Functionally, mutation of the YY1 binding site resulted in a reduction in the RANKL induced TRAP transcription in RAW264.7 cells, demonstrating that YY1 positively regulates RANKL induced TRAP transcriptional activation
Hassan et al., Proc Natl Acad Sci U S A 1992 : Regulatory roles of Fnr, Fur, and Arc in expression of manganese containing superoxide dismutase in Escherichia coli
Fukushima et al., Bone 2005 : The addition of cell-permeable PKI, an inhibitor of the cAMP/PKA signaling pathway, to the cocultures 8 h after the IL-1alpha stimulation inhibited IL-1alpha induced TRAP+ cell formation ... IL-1alpha induced TRAP+ cell formation was completely blocked by either NS398, a selective inhibitor of cyclooxygenase (COX)-2 , or PD98059, a specific inhibitor of extracellular signal regulated kinase ( ERK ) ... IL-1alpha induced TRAP+ cell formation was completely blocked by either NS398, a selective inhibitor of cyclooxygenase (COX)-2, or PD98059, a specific inhibitor of extracellular signal regulated kinase ( ERK ) ... IL-1alpha induced TRAP+ cell formation was completely blocked by either NS398, a selective inhibitor of cyclooxygenase (COX)-2 , or PD98059, a specific inhibitor of extracellular signal regulated kinase ( ERK )
Fukushima et al., J Dent Res 2005 : The PKC inhibitor, Ro-32-0432, suppressed RANKL expression in PDL cells and PTHrP induced TRAP+ cell formation
Pavri et al., Mol Cell 2005 : Importantly, Mediator was inactive ( Cdk8+ ) under basal conditions but was activated ( Cdk8- ) upon induction
Malik et al., Trends Biochem Sci 2005 : Dynamic regulation of pol II transcription by the mammalian Mediator complex
Smith et al., Endocrinology 2005 (Body Weight) : In the arcuate nucleus (Arc) , KiSS-1 expression increased after ovariectomy and decreased with E2 treatment
Ljusberg et al., J Biol Chem 2005 : Activation of TRAP by cathepsin K/L was because of increases in catalytic activity, substrate affinity, and sensitivity to reductants ... Activation of TRAP by cathepsin K/L was because of increases in catalytic activity, substrate affinity, and sensitivity to reductants
Govind et al., Mol Cell Biol 2005 : We confirm the roles of Mediator and SAGA in TATA binding protein (TBP) recruitment and demonstrate that all four coactivators under study enhance Pol II recruitment or promoter clearance following TBP binding
Gaertner et al., J Control Release 2005 : The mechanism by which ARC-encapsulation increased IFN-gamma activity in vivo remains uncertain
Bramham et al., Prog Neurobiol 2005 : Recent experiments suggest that BDNF activates synaptic consolidation through transcription and rapid dendritic trafficking of mRNA encoded by the immediate early gene, Arc
Stephenson et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2005 (Fetal Membranes, Premature Rupture) : TRAP-14 , a thrombin receptor agonist, also significantly increased MMP-9 levels, suggesting that thrombin induced changes in MMP-9 expression were mediated through the thrombin receptor
Soulet et al., Journal of thrombosis and haemostasis : JTH 2005 : Conversely, secreted ADP strongly potentiated Rac activation induced by FcgammaRIIa clustering or TRAP via its P2Y12 receptor, the target of antithrombotic thienopyridines
Takagi et al., J Biol Chem 2006 : Taken together, these findings lead to the suggestion that Mediator is required for basal RNA polymerase II transcription in vivo
Kim et al., J Biol Chem 2006 (Bone Resorption) : We propose that the MCP-1 induced TRAP ( + ) /CTR ( + ) multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity
Sarker et al., Pathophysiol Haemost Thromb 2005 (Calcium Signaling...) : Previously, we showed that thrombin and the thrombin receptor agonist peptide ( TRAP-14 ; SFLLRNPNDKYEPF ) for protease activated receptor 1 (PAR1) induce vascular endothelial growth factor ( VEGF ) secretion in PC-12 cells ... In this study, we show that thrombin and TRAP-14 also stimulate VEGF secretion in the human NB-1 neuroblastoma cells
Wang et al., Neurosci Lett 2006 : Consistent with the literature, Arc , an indicator of synaptic plasticity, was induced by BDNF ( 25 ng/ml ) in both dose- and time dependent manners
Schneider et al., Can J Appl Physiol 2005 : In plasma, LPO decreased from 3589 +/- 193 to 3274 +/- 223 cps x mg Hb ( -1 ) ( p < 0.05 ), and TRAP increased from 304 +/- 45 to 384 +/- 57 micromol x L ( -1 ) trolox ( p < 0.05 ) after high intensity exercise in T. GPx activity increased in the T group as compared to the UT group, after exercise in moderate ( 25.90 +/- 3.79 to 15.05 +/- 3.23 nM x min ( -1 ) x mg protein ( -1 ) ) and high ( 21.75 +/- 4.91 to 12.1 +/- 2.46 nM x min ( -1 ) x mg protein ( -1 ) ) intensities ( p < 0.05 )
Radhakrishnan et al., Cancer Res 2006 (Neoplasms...) : Specifically, ARC inhibits the phosphorylation of RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongation ... Although ARC promoted the accumulation of p53 , ARC induced apoptosis in tumor cells was p53 independent, suggesting that it may be useful for the treatment of tumors with functionally inactive p53
Kim et al., J Biol Chem 2006 : The beta-catenin transactivation domain bound directly to isolated MED12 and intact Mediator both in vitro and in vivo, and Mediator was recruited to Wnt-responsive genes in a beta-catenin dependent manner
Steinberg et al., Endocrinology 2006 (Obesity) : Intracerebroventricular CNTF ( Ax15 ) reduced food intake, increased arcuate nucleus (ARC) signal transducer and activator of transcription 3 phosphorylation, and reduced AMPK signaling but not in the paraventricular nucleus ( PVN ), posterior hypothalamus, or cortex ... Both leptin and CNTF reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the ARC and PVN of control fed mice ... Both leptin and CNTF reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the ARC and PVN of control fed mice
Chen et al., Assay Drug Dev Technol 2006 : Compound 1 did not affect the tumor necrosis factor-alpha- or lipopolysaccharide induced TRAP-luciferase response , suggesting selective inhibition of the RANKL induced pathway
Black et al., Mol Cell 2006 : Using purified proteins, we found that the Mediator regulates this assembly process by binding to p300 and TFIID
Zhou et al., Mol Cell Biol 2006 : We propose that activated Gli3 physically targets the MED12 interface within Mediator in order to functionally reverse Mediator dependent suppression of Shh target gene transcription
Duarte et al., Biochem Biophys Res Commun 2006 : Similarly to thrombin, FGF1 expression and release were induced by TRAP , a specific oligopeptide agonist of PAR1 ... Similarly to thrombin, FGF1 expression and release were induced by TRAP , a specific oligopeptide agonist of PAR1
Tzingounis et al., Neuron 2006 : These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery ... These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2 , two components of the endocytosis machinery
Foo et al., J Biol Chem 2007 (Myocardial Reperfusion Injury) : Here we show that degradation of ARC is dependent on the p53 induced ubiquitin E3 ligase, MDM2 ... Furthermore, ARC degradation requires MDM2 , because MDM2 knock-out fibroblasts showed defective ARC degradation that could be rescued by MDM2
Gopalakrishnan et al., Biochem Cell Biol 2006 (Diabetes Mellitus, Experimental) : In the vertebrae, TRAP activity was elevated as a result of diabetes, but this was prevented by insulin or estradiol
Hunter et al., FEBS Lett 2007 : ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition
Speziani et al., Eur J Immunol 2007 : IL-2, IFN-gamma and IL-4 inhibit TRAP and bone resorption activities contrary to IL-10, which enhances both activities ... IL-2 , IFN-gamma and IL-4 inhibit TRAP and bone resorption activities contrary to IL-10, which enhances both activities ... IL-2, IFN-gamma and IL-4 inhibit TRAP and bone resorption activities contrary to IL-10, which enhances both activities
Meng et al., Anticancer Drugs 2007 (Anoxia) : ARC-111 , a small-molecule topoisomerase I inhibitor , is a potent cytotoxic drug against multiple human cancer cell lines under normoxic conditions ( Li et al., Cancer Res 2003 ; 63 : 8400-8407 )
Arriagada et al., J Steroid Biochem Mol Biol 2007 : We find that both mutation of serine 208 to aspartic acid ( VDRS208D ) or phosphorylation of VDR by CKII enhance the interaction of VDR with DRIP205 in the presence of 1alpha,25-dihydroxy Vitamin D3
Patel et al., Platelets 2007 : Platelet reactivity was evaluated by measuring platelet aggregation, platelet leukocyte aggregates ( PLA ) formation in response to a 6-mer thrombin receptor agonist peptide (TRAP) at a final concentration of 40 microM and flow cytometry determined P-selectin expression induced by ADP, TRAP and arachidonic acid ( AA )
de Foubert et al., Neuroscience 2007 : The present study investigated the effects of 5-HT(6)-receptor activation on hippocampal and cortical levels of mRNA expression of BDNF and Arc in the rat
Boldt et al., Vox Sang 2007 : B-HES but not NB-HES increases the expression of activated platelet GP IIb/IIIa induced by ADP or TRAP
Flaujac et al., Thromb Haemost 2007 (Postoperative Hemorrhage) : Platelet activation marker expression ( CD62P and activated alphaIIbbeta3 ) induced by ADP or TRAP was lower after CPB than before CPB, suggesting a deleterious effect of normothermic CPB on platelet function
Liu et al., Mol Cell Biol 2008 : STAF65gamma is required for SPT3/STAGA interaction with core Mediator and for MYC recruitment of SPT3, TAF9, and core Mediator components to the TERT promoter but is dispensable for MYC recruitment of TRRAP, GCN5, and p300 and for acetylation of nucleosomes and loading of TFIID and RNA polymerase II on the promoter
Li et al., Aging Cell 2007 : Aging up-regulated expression of Bax, Bcl2 and ARC , down-regulated XIAP expression and did not affect p53, pp53 and Omi/HtrA2 ... Aging up-regulated expression of Bax, Bcl2 and ARC , down-regulated XIAP expression and did not affect p53 , pp53 and Omi/HtrA2 ... Aging up-regulated expression of Bax, Bcl2 and ARC , down-regulated XIAP expression and did not affect p53, pp53 and Omi/HtrA2
Ge et al., Mol Cell Biol 2008 : These results indicate that there is a conditional requirement for MED1/TRAP220 and that a direct interaction between PPARgamma and Mediator through MED1/TRAP220 is not essential either for PPARgamma stimulated adipogenesis or for PPARgamma target gene expression in cultured fibroblasts ... As Mediator is apparently essential for PPARgamma transcriptional activity, our data indicate the presence of alternative mechanisms for Mediator recruitment, possibly through intermediate cofactors or other cofactors that are functionally redundant with MED1/TRAP220
Leite et al., J Neuroendocrinol 2008 : ERalpha expression in TH-ir neurones increased at 14 and 16 h in the rostral-ARC and dorsomedial-ARC, 14 h in the caudal-ARC and 16 h in the VMPO, whereas it was unaltered in the ventrolateral-ARC, periventricular and AVPe
Echeverria et al., Curr Alzheimer Res 2007 : Using a model of synaptic plasticity in which BDNF increases Arc expression in cultured cortical neurons, we have found that an oligomeric form of Abeta strongly inhibits the BDNF induced increase of Arc expression
Ariyoshi et al., J Cell Biochem 2008 (Bone Resorption) : Heparin suppressed TRAP positive multinucleated cell formation and TRAP activity induced by RANKL , whereas the other GAGs showed no effects on osteoclast differentiation
Christersson et al., Journal of thrombosis and haemostasis : JTH 2008 : TRAP and P-selectin increased TF, IL8 , and MCP-1 mRNA in whole blood and purified monocytes
Belakavadi et al., Mol Cell Biol 2008 : Here, we report that phosphorylation of MED1 by mitogen activated protein kinase-extracellular signal regulated kinase ( MAPK-ERK ) promotes its association with Mediator
Mancino et al., Dig Liver Dis 2009 (Bile Duct Neoplasms...) : 17beta-Estradiol stimulated proliferation of HuH-28 cells was blocked by 70 % by VEGF-TRAP , a receptor based VEGF inhibitor
Contreras-Levicoy et al., FEBS J 2008 : Activation of transcription by PC4 was dependent on the Mediator complex and TFIIA, but was independent of TATA binding protein associated factor
Kauskot et al., Frontiers in bioscience : a journal and virtual library 2008 : The disintegrin inhibited the binding of FITC-fibrinogen and FITC-PAC-1 to ADP stimulated platelets and inhibited ADP-, TRAP- and collagen induced aggregation of murine, rabbit or human platelets ... The disintegrin inhibited the binding of FITC-fibrinogen and FITC-PAC-1 to ADP stimulated platelets and inhibited ADP-, TRAP- and collagen induced aggregation of murine, rabbit or human platelets
Keifer et al., Neurobiol Learn Mem 2008 (Synaptic Transmission) : The results are consistent with the interpretation that synaptic incorporation of GluR4 containing AMPARs supports the expression of CRs in this preparation, and that Arc may be involved in trafficking of GluR4 subunits during conditioning
Karanasios et al., J Mol Biol 2008 : Furthermore, the C-terminal part of Arc1p harbors a conserved tRNA binding domain ( TRBD ) required for the Arc1p dependent stimulation of the catalytic activity of MetRS
Tsutsui et al., Genes Cells 2008 : While the role of CDK8 has been studied extensively, little is known of the role of CDK11 in Mediator
Thiaville et al., Nucleic Acids Res 2008 : It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress
Zheng et al., J Neurosci Res 2009 : In contrast, chelating intracellular calcium ( [ Ca ( 2+ ) ] ( i ) ) by BAPTA-AM abolished BDNF mediated Arc up-regulation ... Surprisingly, BAPTA-AM did not block ERK activation, indicating that [ Ca ( 2+ ) ] ( i ) and Ras-Raf-MAPK are not coupled, and the activation of ERK alone is not sufficient to up-regulate Arc transcription ... Moreover, we found that inhibition of calmodulin (CaM) by W13 blocked both Arc transcription and ERK activation, revealing a Ca ( 2+ ) -independent function of CaM
Ambati et al., Biofactors 2007 (Body Weight) : Leptin and CNTF increased ARC-ME mRNA levels of signal transducer and activator of transcription 3 ( STAT3 ) by 64.5 and 124.7 % ( p < 0.01 ), suppressor of cytokine signaling 3 ( SOCS3 ) by 258.9 and 1063.9 % ( p < 0.01 ), cocaine and amphetamine regulated transcript ( CART ) by 102.7 and 123.1 % ( p < 0.01 ), and proopiomelanocortin ( POMC2 ) by 374.1 and 264.9 % ( p < 0.01 ), respectively ... Leptin and CNTF increased ARC-ME mRNA levels of signal transducer and activator of transcription 3 ( STAT3 ) by 64.5 and 124.7 % ( p < 0.01 ), suppressor of cytokine signaling 3 ( SOCS3 ) by 258.9 and 1063.9 % ( p < 0.01 ), cocaine and amphetamine regulated transcript ( CART ) by 102.7 and 123.1 % ( p < 0.01 ), and proopiomelanocortin ( POMC2 ) by 374.1 and 264.9 % ( p < 0.01 ), respectively
Chauleur et al., Journal of thrombosis and haemostasis : JTH 2008 (Postpartum Hemorrhage) : From values obtained 6-9 months after delivery, low ( but not-deficient ) levels of fibrinogen, von Willebrand factor (VWF) antigen, factor (F) XI, platelet CD42b, TRAP induced increase of platelet CD41a and high values of serum residual prothrombin activity or closure aperture times using the collagen-ADP cartridge on the PFA-100 system, and blood group O, were independently associated with a significant risk of severe PPH. Being positive for at least two of these eight variables was found in 1.6 %, 3.5 % and 20.8 % of the women from the C, the NS-PPH and the S-PPH groups, respectively, the odds ratio for S-PPH in such a case being 16.4, 95 % CI ( 6.5-41 ), P < 0.0001
Messerli et al., Phytother Res 2009 (Neoplasms, Experimental...) : Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice ... Also it was demonstrated that ARC suppresses angiogenesis, suggesting the possibility that ARC also blocks oncogenic PAK1 signaling ... Here it is shown for the first time that both ARC and green propolis extract ( GPE ) indeed block the PAK1 signaling selectively, without affecting another kinase known as AKT
Bae et al., Thromb Haemost 2009 : Furthermore, similar to activated protein C, both thrombin and TRAP activated Rac1 and inhibited the activation of RhoA and NF-kappaB pathways in response to TNF-alpha in cells pretreated with protein C-S195A ... Furthermore, similar to activated protein C, both thrombin and TRAP activated Rac1 and inhibited the activation of RhoA and NF-kappaB pathways in response to TNF-alpha in cells pretreated with protein C-S195A
Chen et al., J Neurosci Res 2009 : In this study, BDNF treatment alone induced the activation of the phosphatidylinositol 3-kinase-Akt-mammlian target of rapamycin ( PI3K-Akt-mTOR ) signaling pathway, the phosphorylation of eukaryotic initiation factor 4E binding protein ( 4EBP1 ) and p70 ribosomal S6 kinase (p70S6K), the dephosphorylation of eukaryotic elongation factor 2 ( eEF2 ), and the expression of Arc
Simpson et al., Arq Bras Endocrinol Metabol 2009 (Obesity) : Firmly established pathways involve the orexigenic NPY/AgRP and the anorexigenic POMC/CART neurons in the arcuate nucleus (ARC) of the hypothalamus ... Firmly established pathways involve the orexigenic NPY/AgRP and the anorexigenic POMC/CART neurons in the arcuate nucleus (ARC) of the hypothalamus
Chandler et al., Thromb Res 2010 (Coronary Disease) : Platelet activation by adenosine diphosphate ( ADP ) or thrombin agonist peptide (TRAP) increased CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold ... Platelet activation by adenosine diphosphate ( ADP ) or thrombin agonist peptide (TRAP) increased CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold
Kirk et al., PloS one 2009 (Hyperphagia...) : At postnatal Day 30, before the onset of hyperphagia in these animals, serum leptin is normal, but leptin induced appetite suppression and phosphorylation of STAT3 in the arcuate nucleus (ARC) are attenuated ; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus ( PVH ), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished
Villanueva et al., Endocrinology 2009 : Furthermore, ghrelin, which activates orexigenic ARC neurons, increased ARC mTORC1 activity and induced colocalized pS6- and c-Fos-IR
Kim et al., J Cell Physiol 2009 (Bone Resorption) : We found that saurolactam was one of the compounds inhibiting the RANKL induced osteoclastogenesis ; it significantly inhibited the RANKL induced TRAP activity and formation of multinucleated osteoclasts without any cytotoxicity
Konda et al., Journal of inflammation (London, England) 2009 : The inhibitory effect of RIAA on inflammatory markers was assessed by measuring nitric oxide in LPS stimulated RAW 264.7 cells, RANKL mediated TRAP activity in transformed osteoclasts, and TNF-alpha/IL-1beta mediated MMP-13 expression in SW1353 cells ... In addition, RIAA inhibited NF-kappaB mediated inflammatory markers in various cell models, including nitric oxide in LPS stimulated RAW 264.7 cells, RANKL mediated TRAP activity in transformed osteoclasts, and TNF-alpha/IL-1beta mediated MMP-13 expression in SW1353 human chondrosarcoma cells ... In addition, RIAA inhibited NF-kappaB mediated inflammatory markers in various cell models, including nitric oxide in LPS stimulated RAW 264.7 cells, RANKL mediated TRAP activity in transformed osteoclasts, and TNF-alpha/IL-1beta mediated MMP-13 expression in SW1353 human chondrosarcoma cells
Mazière et al., J Cell Physiol 2009 (Bone Resorption) : Finally, OxLDL also prevented RANKL induced TRAP activity and RANKL induced bone resorbing activity of human peripheral blood mononuclear cells
Panja et al., J Biol Chem 2009 : These results support a dominant role for ERK-MNK signaling in control of translational initiation and Arc synthesis during LTP consolidation in the dentate gyrus ... These results support a dominant role for ERK-MNK signaling in control of translational initiation and Arc synthesis during LTP consolidation in the dentate gyrus
Yu et al., J Biol Chem 2009 : To determine whether IL-4 regulates TRAP promoter activity, RAW264.7 cells were transfected with a TRAP promoter-luciferase reporter ... STAT6VT did not inhibit the potent up-regulation of TRAP promoter activity caused by overexpression of NFATc1, PU.1, and microphthalmia transcription factor, downstream targets of macrophage colony stimulating factor and RANKL ... Knockdown of NFATc1 by short interfering RNA caused TRAP expression to be down-regulated, and ectopic expression of NFATc1 abrogated the IL-4 induced down-regulation of TRAP ... These results suggest that STAT6 plays two distinct roles in TRAP expression ... However, in the absence of RANKL and osteoclast differentiation, STAT6 binds the TRAP promoter after IL-4 treatment and directly enhances TRAP expression ... However, in the absence of RANKL and osteoclast differentiation, STAT6 binds the TRAP promoter after IL-4 treatment and directly enhances TRAP expression
Frank et al., Brain Behav Immun 2010 (Escherichia coli Infections...) : IL-1RA blocks E. coli induced suppression of Arc and long-term memory in aged F344xBN F1 rats
Schwartz et al., Endocrinology 1991 (Obesity) : Thus, insulin reduced the expression of mRNA for NPY specifically in the ARC
Kim et al., J Cell Physiol 2010 (Colonic Neoplasms) : Indeed, ARC-G blocked expression of UPR target genes such as phosphorylated-PERK, ATF4, CHOP , and GRP78, which was accompanied by enhanced phosphorylation of eIF2 alpha during glucose deprivation ... Indeed, ARC-G blocked expression of UPR target genes such as phosphorylated-PERK, ATF4, CHOP, and GRP78 , which was accompanied by enhanced phosphorylation of eIF2 alpha during glucose deprivation ... Indeed, ARC-G blocked expression of UPR target genes such as phosphorylated-PERK, ATF4 , CHOP, and GRP78, which was accompanied by enhanced phosphorylation of eIF2 alpha during glucose deprivation
Qi et al., Endocrinology 2010 : It is widely accepted that leptin acts on first-order neurons in the arcuate nucleus (ARC) with information then relayed to other hypothalamic centers ... We used a model of hypothalamo-pituitary disconnection ( HPD ) to determine whether leptin action on appetite regulating systems requires the ARC
Crespin et al., Blood Coagul Fibrinolysis 2009 : Inhibition of Cdc42 and Rac1 by toxin B from Clostridium difficile, that suppresses PAK1/2 activation induced by TRAP and collagen or by A23187 in the presence of calpeptin, decreases polymerization of actin, lamellipodia and filopodia formation and interferes with the shedding of microvesicles
Li et al., Apoptosis 2010 : ARC ( apoptosis repressor with caspase recruitment domain ), an abundantly expressed apoptotic repressor in cardiomyocytes, could inhibit mitochondrial fission and Smac/DIABLO release
Carey et al., Cold Spring Harbor protocols 2010 : INTRODUCTION : The Mediator ( Med ) complex plays a key role in promoter-specific activation of transcription by RNA polymerase II (Pol II)
Kunin et al., PloS one 2010 : Mediator of DNA damage checkpoint 1 ( MDC1 ) contributes to high NaCl induced activation of the osmoprotective transcription factor TonEBP/OREBP
Arzamendi et al., Clin Appl Thromb Hemost 2011 (Coronary Artery Disease...) : In contrast to abciximab, ARC1779 did not significantly affect platelet aggregation, P-selectin expression, and platelet-leukocyte binding
Xu et al., EMBO Rep 2011 (Alzheimer Disease) : Mediator , in a MED12 dependent manner, occupies only AICD bound promoter DNA, indicating that the AICD recruits Mediator to activate transcription
Harlan et al., Circ Res 2011 (Disease Models, Animal...) : These data demonstrate a critical role for ObR in the ARC in mediating the sympathetic nerve responses to leptin and in the adverse sympathoexcitatory effects of leptin in obesity
Alberi et al., Neuron 2011 : Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation
Quennell et al., Endocrinology 2011 (Body Weight...) : In mice with normalized levels of estradiol, leptin deficiency markedly reduced kisspeptin gene expression, particularly in the arcuate nucleus (ARC) , and kisspeptin immunoreactive cell numbers in the rostral periventricular region of the third ventricle ( RP3V )
Roth et al., Pediatr Res 2011 (Body Weight...) : We compared the metabolic phenotype of animals with three distinct types of hypothalamic lesions : 1 ) destruction of the arcuate nucleus (ARC) induced by monosodium glutamate ( MSG ), 2 ) electrolytic lesion of the adjacent ventromedial nucleus ( VMN ) alone, 3 ) both the VMN and dorsomedial nucleus (DMN) , or a 4 ) combined medial hypothalamic lesion ( CMHL ) affecting the VMN, DMN, and the ARC
Franco et al., Exp Cell Res 2011 (Bone Resorption) : Furthermore, MMP-9 enzyme inhibitor also attenuated both RANKL induced osteoclastogenesis and up-regulation of TRAP and cathepsin K mRNA expression, indicating that MMP-9 enzyme action is engaged in the promotion of RANKL induced osteoclastogenesis ... Furthermore, MMP-9 enzyme inhibitor also attenuated both RANKL induced osteoclastogenesis and up-regulation of TRAP and cathepsin K mRNA expression, indicating that MMP-9 enzyme action is engaged in the promotion of RANKL induced osteoclastogenesis ... Finally, Dox treatment abrogated RANKL induced osteoclastogenesis and TRAP activity in mouse calvaria along with the suppression of MMP9 enzyme activity, again without affecting the expression of MMP9 protein
Zheng et al., Curr Eye Res 2011 (Cataract) : Its downstream p53 was inhibited, and FOXO pathway was activated, indicating that SIRT1 may play a protective role in ARC formation
Andino et al., J Endocrinol 2011 (Body Weight...) : Interestingly, tyrosine hydroxylase levels were increased in both the ARC and VTA with POMC overexpression in either the ARC or the VTA
Corbin et al., International journal of nephrology and renovascular disease 2011 : Active renin mass concentration (ARC) is independent of the endogenous level of angiotensinogen , and less variable and more reproducible than plasma renin activity
Resch et al., Am J Physiol Regul Integr Comp Physiol 2011 : One hour after PACAP administration, expression of pro-opiomelanocortin mRNA was significantly increased in the arcuate nuclei (ARC) , with no changes in neuropeptide Y and agouti related polypeptide mRNA levels
Lin et al., Genes Dev 2011 : Studies in depleted extracts showed that the Mediator coactivator complex, which controls PIC assembly, is also necessary for CHD1 recruitment
Kumar et al., J Biol Chem 2012 (Synaptic Transmission) : Mechanistically, intracellular mGluR5 mediated Arc induction is dependent upon extracellular and intracellular Ca ( 2+ ) and ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ ) /calmodulin dependent protein kinase II construct block Arc increases ... Mechanistically, intracellular mGluR5 mediated Arc induction is dependent upon extracellular and intracellular Ca ( 2+ ) and ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ ) /calmodulin dependent protein kinase II construct block Arc increases ... Mechanistically, intracellular mGluR5 mediated Arc induction is dependent upon extracellular and intracellular Ca ( 2+ ) and ERK1/2 as well as calmodulin dependent kinases as known chelators, inhibitors, and a dominant negative Ca ( 2+ ) /calmodulin dependent protein kinase II construct block Arc increases ... Moreover, intracellular mGluR5 induced Arc expression requires the serum response transcription factor ( SRF ) as wild type but not SRF-deficient neurons show this response ... Moreover, intracellular mGluR5 induced Arc expression requires the serum response transcription factor ( SRF ) as wild type but not SRF-deficient neurons show this response
Yi et al., Diabetes 2012 (Insulin Resistance) : Antagonizing the NPY1 receptors by intracerebroventricular infusion of its antagonist largely blocked the hepatic insulin resistance induced by dexamethasone in the ARC
An et al., Hepatology 2012 (Disease Models, Animal...) : Here, we investigated the in vivo effects of ARC fused with the transduction domain of human immunodeficiency virus 1 ( HIV-1 ) ( TAT-ARC ) on Fas- and tumor necrosis factor (TNF) mediated murine models of fulminant liver failure
Ang et al., PLoS Biol 2012 : Furthermore, we have found that Mediator controls the galactose induced protein degradation of Gal80 , which places Mediator genetically upstream of the activator Gal4 ... Furthermore, we have found that Mediator controls the galactose induced protein degradation of Gal80, which places Mediator genetically upstream of the activator Gal4
Holloway-Erickson et al., Frontiers in behavioral neuroscience 2012 : Memory modulating BLA manipulations influence expression of the protein product of the immediate early gene activity regulated cytoskeletal associated protein ( Arc ) in the dorsal hippocampus, and hippocampal expression of Arc protein is critically involved in memory consolidation and long-term potentiation
Tai et al., Blood 2012 (Multiple Myeloma...) : PCI-32765 blocked RANKL/M-CSF induced phosphorylation of Btk and downstream PLC-?2 in OCs, resulting in diminished TRAP5b ( ED50 = 17 nM ) and bone resorption activity ... PCI-32765 blocked RANKL/M-CSF induced phosphorylation of Btk and downstream PLC-?2 in OCs, resulting in diminished TRAP5b ( ED50 = 17 nM ) and bone resorption activity
Zhang et al., Biochimie 2012 (Bone Resorption) : Besides, RANKL induced osteoclast formation from RAW 264.7 cells and the expression of TRAP , CA II, CTSK and MMP-9 was significantly reduced by the treatment of 25 µM HEF and 17ß-estradiol ( ES ), and the inhibitory strength increases in the order TF < ES < ICA < BS, which was blocked by ICI182780 suggesting that the regulation of osteoclast activity might be ER dependent
Chitu et al., Blood 2012 (Bone Diseases, Metabolic...) : PSTPIP2 tyrosine phosphorylation and a functional F-BAR domain were essential for PSTPIP2 inhibition of TRAP expression and osteoclast precursor fusion, whereas interaction with PEST-type phosphatases was only required for suppression of TRAP expression
Riediger et al., Proc Nutr Soc 2012 (Obesity...) : PYY and leptin also reverse or prevent fasting induced activation of the ARC ... PYY and leptin also reverse or prevent fasting induced activation of the ARC
Tong et al., J Neurosci 2012 : Using rat organotypic hippocampal cultures, we found that IL-1ß suppressed BDNF dependent regulation of Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a transcription factor regulating Arc expression ... Using rat organotypic hippocampal cultures, we found that IL-1ß suppressed BDNF dependent regulation of Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a transcription factor regulating Arc expression ... Using rat organotypic hippocampal cultures, we found that IL-1ß suppressed BDNF dependent regulation of Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a transcription factor regulating Arc expression
Povolny et al., Exp Hematol 1990 : In addition, the effect of 1,25-dihydroxyvitamin D3 ( calcitriol ) on CSF induced colony growth and TRAP expression was also determined
Lewis et al., Clin Exp Allergy 2013 : Mediator release induced by SCF was accompanied by the up-regulation of the activation marker, CD63
Tikhonova et al., Chin J Physiol 2012 : BDNF also augmented mRNA levels of Arc gene encoding Arc ( Activity regulated cytoskeleton associated ) protein involved in BDNF induced processes of neuronal and synaptic plasticity in hippocampus and prefrontal cortex
Naidu et al., Chem Biol Interact 2013 (Arthritis, Experimental...) : The peptide YR-11 ( YLEIEFSLKHR ), obtained by direct substitution of cysteine with a serine residue in the template sequence, significantly ( p < 0.05 ) inhibited RANK-RANKL binding, and RANKL induced TRAP activity and formation of multinucleated osteoclasts without any cytotoxicity
Gremmel et al., Translational research : the journal of laboratory and clinical medicine 2013 (Obesity...) : Finally, PAR-1 mediated platelet activation as assessed by expression of P-selectin and activated GPIIb/IIIa in response to TRAP-6 was significantly more pronounced in obese patients than in patients without obesity ( both P = 0.02 ) ... Finally, PAR-1 mediated platelet activation as assessed by expression of P-selectin and activated GPIIb/IIIa in response to TRAP-6 was significantly more pronounced in obese patients than in patients without obesity ( both P = 0.02 )
Lu et al., J Biol Chem 2013 (Calcium Signaling...) : Moreover, we showed that Foxo3a activates ARC expression by directly binding to its promoter
Kim et al., J Biol Chem 2013 : Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16 ... Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16
Verger et al., Nucleic Acids Res 2013 : We further show that depletion of MED25 disrupts the association of ERM with the Mediator in vitro
Chen et al., Int J Biochem Cell Biol 2013 : When stimulated with 12-O-tetradecanoylphorbol 13-acetate ( TPA ) or CD437, this TR3-TRAP? interaction not only induced Ca ( 2+ ) depletion in the endoplasmic reticulum ( ER ) but also promoted the expression of the proapoptotic transcriptional regulator CHOP
Galbraith et al., Cell 2013 (Neoplasms) : HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia ... HIF1A induces binding of CDK8-Mediator and the super elongation complex ( SEC ), containing AFF4 and CDK9, to alleviate RNAPII pausing
Šedý et al., J Immunol 2013 (Inflammation) : CD160 Activation by Herpesvirus Entry Mediator Augments Inflammatory Cytokine Production and Cytolytic Function by NK Cells
Liou et al., PloS one 2013 (Osteoporosis) : In addition, KMUP-1 inhibited RANKL induced activation of signaling molecules ( Akt, MAPKs, calcium and NF-?B ), mRNA expression of osteoclastogensis associated genes ( TRAP , MMP-9, Fra-1, and cathepsin K ) and transcription factors ( c-Fos and NFATc1 )
Pan et al., Neuroendocrinology 1986 : In the ARC , however, CCK-8S may play some functional roles that are influenced by estrogen
Newman et al., Endocrinology 1985 : Mediator generation was rapid, with a half-time of approximately 45 sec and was insulin dose dependent
Shankar et al., J Biol Chem 1994 : Furthermore, the stimulation of E-selectin cell surface expression and the steady-state E-selectin mRNA levels by thrombin and TRAP were comparable ... Northern analysis, however, revealed that TRAP at 100 microM stimulated PDGF-A and -B chain mRNA expression to a level similar to that induced by thrombin ... Northern analysis, however, revealed that TRAP at 100 microM stimulated PDGF-A and -B chain mRNA expression to a level similar to that induced by thrombin
Korthäuer et al., Nature 1993 (Hypergammaglobulinemia...) : The resultant failure of TRAP to interact with CD40 on functionally intact B cells is responsible for the observed immunoglobulin isotype defect in HIGM1
Nakamura et al., Am J Physiol 1995 : Plasmin inhibited the thrombin evoked increase in cytosolic Ca2+ and also inhibited the Ca2+ response to the tethered peptide TRAP-6 of the thrombin receptor
Kruse et al., Am J Physiol 1995 : Receptor operated effects of alpha-thrombin and of the thrombin receptor activating peptide TRAP14 on cytoplasmic Ca2+ concentration ([Ca2+]i) were examined in fura 2-loaded endothelial cells
Kalra et al., Brain Res 1994 : The results showed that IL-1 beta increased NKA-li selectively in the median eminence ( ME ) and arcuate nucleus (ARC) of castrated rats only. ( ABSTRACT TRUNCATED AT 250 WORDS )
Maruyama et al., Biochem Biophys Res Commun 1994 : TRAP induced rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin , platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1
de la Piedra et al., Horm Metab Res 1993 (Bone Resorption) : In the present work, 10 ( -7 ) M PTH ( 1-34 ), 10 ( -7 ) M PTHrP ( 1-34 ) and 10 ( -8 ) M or 10 ( -10 ) M 1,25 ( OH ) 2D3 produced a significant increase in TRAP activity, when these agonists were added to the calvaria culture
Kasono et al., Bone Miner 1993 (Bone Resorption) : The minimum effective inhibitory concentration was 0.01 ng/ml, and 1 ng/ml IL-4 completely inhibited TRAP ( + ) MNC formation
Jenkins et al., J Cell Sci 1995 : The use of alanine substituted peptides demonstrated that the Ca2+ response was due to TRAP stimulation of a receptor other than the proteolytically activated thrombin receptor
Kanthou et al., Thromb Haemost 1995 : Examination of thrombin and TRAP treated cells by immunofluorescence staining followed by computer assisted image analysis revealed that thrombin and to a lesser extent TRAP induced PDGF-AA protein expression
Michelson et al., Blood 1996 : First, although only the GPIb alpha subunit of this putative complex is known to be directly linked to the platelet cytoskeleton via actin binding protein, cytochalasin B inhibited the ADP/epinephrine-, cathepsin G-, and TRAP induced decrease in platelet surface GPV
Jiang et al., Circ Res 1996 : Differences in the kinetics and magnitude of thrombin- and TRAP dependent inositol phosphate ( IP ) accumulation are paralleled by differences in the kinetics and magnitude of thrombin- and TRAP dependent activation of MAPK
Blackhart et al., J Biol Chem 1996 : PAR-2 was also found to be responsive to TRAP ( EC50 = 1 microM ) but was unresponsive to Xenopus TRAP ( 50 microM )
Satoh et al., Biochem Biophys Res Commun 1996 : Both thrombin and TRAP induced translocation of p60c-src and p54/58lyn to cytoskeleton in an aggregation dependent manner ... Both thrombin and TRAP induced translocation of p60c-src and p54/58lyn to cytoskeleton in an aggregation dependent manner ... Both thrombin and TRAP induced translocation of p60c-src and p54/58lyn to cytoskeleton in an aggregation dependent manner ... In contrast, TRAP , even at concentrations as high as 100 mu M, did not induce p72syk translocation to cytoskeleton
Faraday et al., Thromb Haemost 1997 : Similarly, the number of GPIIb-IIIa receptors capable of binding PAC-1 in response to ADP and TRAP was 50 % to 80 % greater in women than men
Minami et al., J Endocrinol 1997 : Together with the results of our previous studies showing that c-fos gene expression was induced by systemic administration of GH and that GH receptor mRNA was contained in somatostatin neurons in the PeV and NPY neurons in the ARC, the data of the present study indicate that GH, but not IGF-I , acts on the cells in the ARC and the PeV or in their vicinity to inhibit its own secretion, presumably by activating the somatostatin and NPY neurons
Lin et al., Sheng Li Xue Bao 1996 : In this group, brain ANP increased in the periventricular nuclues ( PVN ) and arcute nucleus (Arc) ( P < 0.05 )
Sahu et al., Endocrinology 1998 : In addition, in the ARC and MPOA, the other hypothalamic sites associated with induction of LH surge, NPY levels increased before and during the LH surge in young rats, no change in NPY levels in these nuclei was observed in association with the attenuated LH surge in MA rats
Kim et al., Brain Res 1998 (Hyperphagia) : Animals receiving the HPD ad libitum consumed more calories and gained more weight than animals receiving the BCD ( P < 0.001 ). The HPD did not affect ARC NPY mRNA levels, whether the subjects were allowed to overeat or pair fed to the BCD ( P > 0.05 )
Xirasagar et al., J Biol Chem 1998 : This conclusion is based on the effects of temperature and Mg2+ on the affinity of TRAP for RNAs with CC spacers combined with UV hyperchromicity and circular dichroism
Elias et al., Neuron 1998 (Body Weight) : We found that leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral arcuate nucleus (Arc) that innervate the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )
Han et al., Mol Cell Biol 1999 : The multisubunit Mediator complex of Saccharomyces cerevisiae is required for most RNA polymerase II (Pol II) transcription