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RAC3 — WNT4

Text-mined interactions from Literome

Habas et al., Genes Dev 2003 : Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK) ... Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the Wnt induced Dvl-Rho complex
Habas et al., Methods Enzymol 2006 : Activation of Rho and Rac by Wnt/frizzled signaling ... Wnt/Fz activation of the small GTPases Rho and Rac has emerged as a key mechanism that regulates cell polarity and movements during vertebrate gastrulation ... In this chapter, we describe biochemical assays for the detection of Wnt/Fz activation of Rho and Rac in both mammalian cells and Xenopus embryo explants
Shi et al., Mol Cell Biol 2006 : Noncanonical Wnt/Fz signaling activates RhoA and Rac , and the latter triggers the activation of c-Jun N-terminal kinase (JNK)
Upadhyay et al., Oncogene 2008 : Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling ... We report that DOCK4, a guanine nucleotide exchange factor (GEF) for Rac and a member of the CDM family of unconventional GEFs, mediates Wnt induced Rac activation in the canonical Wnt/beta-catenin pathway ... Furthermore, we observe that DOCK4 is phosphorylated by GSK3beta, which enhances Wnt induced Rac activation
Mezzacappa et al., Methods Mol Biol 2012 : The Rho family of small GTPases are activated and required for non-canonical Wnt signaling during gastrulation, and in this chapter, we describe biochemical assays for the detection of Wnt mediated activation of Rho, Rac , and Cdc42 in both mammalian cells and Xenopus embryo explants