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TBK1 — TLR3

Pathways - manually collected, often from reviews:

• Reactome Reaction: TLR3 → TBK1 (indirect_complex) Fitzgerald et al., Nat Immunol 2003, Hemmi et al., J Exp Med 2004, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Larabi et al., Cell reports 2013
• Reactome Reaction: TLR3 → TBK1 (reaction) Fitzgerald et al., Nat Immunol 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Panne et al., J Biol Chem 2007, Larabi et al., Cell reports 2013

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TBK1 — TLR3 (physical association, affinity chromatography technology) Yang et al., J Exp Med 2011

Text-mined interactions from Literome

Sankar et al., Cell Signal 2006 : Although the literature to date suggests that IKK-i and TBK1 play redundant roles in TLR3 and TLR4 signaling, recent data suggest that there may be subtle differences in the signaling pathways affected by these kinases
Clark et al., Proc Natl Acad Sci U S A 2011 : Here we show that TBK1 and IKKe are also activated by TLR ligands that signal via MyD88