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NA — TP53

Text-mined interactions from Literome

Wu et al., J Pharmacol Exp Ther 2005 : Expression of tumor suppressor p53 and the cell cycle regulatory protein p21 was stimulated within 5 to 10 min by cisplatin in p53 positive LX-1 small cell lung carcinoma cells, and this effect was blocked by NAC
Park et al., FEBS Lett 2007 : And DPI induced p53 expression was not affected by the ROS scavenger NAC
Huang et al., J Pharmacol Sci 2008 (Carcinoma, Hepatocellular...) : Moreover, the ROS activated the p38 kinase, which in turn promoted the activation of p53, as verified by evidence showing that the ROS scavenger N-acetyl-cysteine (NAC) not only blocked the phosphorylation of p38 but also partially inhibited the activation of p53 , and the p38 inhibitor SB203580 reduced the activation of p53 as well
Shi et al., BMC cancer 2008 (Pancreatic Neoplasms) : Moreover, NAC or U0126 pretreatment significantly attenuated Triphala induced p53 transcriptional activity
Sun et al., Biochem Pharmacol 2010 (MAP Kinase Signaling System...) : NAC subsequently inhibited BEL induced activation of p38 and p53 in LNCaP cells
Gerona et al., J Ocul Pharmacol Ther 2010 : NAC prevents the increased expression levels of p53 and CASP8 induced by long-term maintained hypoxia
Hann et al., J Exp Clin Cancer Res 2013 : NAC induced p53 and reduced p65 protein expression through activation of PPARa