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PCSK4 — TP53

Text-mined interactions from Literome

Banerjee et al., Mol Cell Biol 2004 : Here we report that human transcriptional coactivator PC4 enhances the DNA binding of p53 to its cognate site in vitro and directly interacts with p53 in vivo ... We also demonstrated that PC4 can stimulate p53- and p53Delta30 mediated transactivation from a p53-responsive promoter
Batta et al., Mol Cell Biol 2007 : In conclusion, PC4 activates p53 recruitment to p53-responsive promoters ( Bax and p21 ) in vivo through its interaction with p53 and by providing bent substrate for p53 recruitment
Debnath et al., J Biol Chem 2011 : We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes