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NEUROD1 — WNT1
Text-mined interactions from Literome
Lyu et al., J Biol Chem 2003
(Carcinoma, Embryonal) :
To test the
role of
Wnt signaling in
neuronal differentiation , embryonal carcinoma P19 cells ( P19 EC ), which can be stimulated to differentiate into a neuron-like phenotype in response to retinoic acid ( RA ), were used
Hirabayashi et al., Development 2004
:
Here, we show that
Wnt signaling inhibits the self-renewal capacity of mouse cortical NPCs, and instructively
promotes their
neuronal differentiation
Hirabayashi et al., Neurosci Res 2005
:
For example, we have shown that
Wnt signaling
induces neuronal differentiation of NPCs in an instructive manner
Yamaguchi et al., Development 2005
:
Canonical
Wnt signaling promotes the proliferation of retinal cells in zebrafish, and Notch signaling
inhibits neuronal differentiation through the activation of a neurogenic inhibitor, Hairy/Enhancer-of-split ( Hes )
Hirsch et al., Exp Cell Res 2007
:
During the expansion and neurogenic phases of embryonic neural development canonical
Wnt signaling initially
controls proliferation of neural progenitor cells, and later
neuronal differentiation
Olivera-Martinez et al., Development 2007
:
Wnt signals then act here to
repress neuronal differentiation
Kuwabara et al., Nat Neurosci 2009
:
Wnt mediated activation of
NeuroD1 and retro-elements during adult neurogenesis ... We found that
Wnt signaling, together with the removal of Sox2,
triggered the expression of
NeuroD1 in mice
Munji et al., J Neurosci 2011
:
Wnt signaling
regulates neuronal differentiation of cortical intermediate progenitors
Kondo et al., Stem Cells 2011
:
Wnt signaling
promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3 ... Consistent with our hypothesis,
Wnt1 induced expression of sensory neuron markers including Ngn1,
NeuroD , and Brn3a, as well as glutamatergic markers in neurally induced MSCs in vitro and promoted engraftment of transplanted MSCs in the inner ear bearing selective loss of sensory neurons in vivo
Slawny et al., Mol Cell Neurosci 2011
(Wnt Signaling Pathway) :
Dynamic changes in
Wnt signaling are
required for
neuronal differentiation of mouse embryonic stem cells
Rogers et al., Br J Cancer 2012
(Cell Transformation, Neoplastic...) :
WNT/ß-catenin pathway activation in Myc immortalised cerebellar progenitor cells
inhibits neuronal differentiation and generates tumours resembling medulloblastoma ...
Wnt1 overexpression
inhibited neuronal differentiation in vitro, suggesting WNT/ß-catenin pathway activation prevents cells terminally differentiating, maintaining them in a more ` stem-like ' state
Wang et al., Dev Cell 2012
(Wnt Signaling Pathway) :
Previous studies have raised the possibility that
Wnt signaling may
regulate both neural progenitor maintenance and
neuronal differentiation within a single population
Rampazzo et al., Cell death & disease 2013
(Glioblastoma...) :
Wnt activation
promotes neuronal differentiation of Glioblastoma
Rosso et al., Frontiers in cellular neuroscience 2013
:
In the nervous system,
Wnt signaling also
regulates the formation and function of neuronal circuits by controlling
neuronal differentiation , axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity