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BMP4 — IHH
Text-mined interactions from Literome
Kameda et al., Genes Cells 1999
:
Developmental patterning in chondrocytic cultures by morphogenic gradients :
BMP induces expression of
indian hedgehog and noggin
Vortkamp et al., Osteoarthritis Cartilage 2001
:
Alternatively
BMP signalling,
induced by
Ihh , might reciprocally act back on the prehypertrophic chondrocytes, thereby coordinating hypertrophic differentiation with the differentiation of the periosteum
Minina et al., Dev Cell 2002
(Hypertrophy) :
We furthermore found that FGF and
BMP signaling
act in an antagonistic relationship regulating chondrocyte proliferation,
Ihh expression, and the process of hypertrophic differentiation
Zhang et al., J Bone Miner Res 2003
:
The findings show that
BMP signaling
induces Ihh
Ionescu et al., J Cell Physiol 2004
:
In contrast, PTHrP which activates CREB signaling, blocked the stimulatory effect of BMP-2 on colX and
Ihh , but minimally
inhibited the stimulatory effect of
BMP on Smad6
Katoh et al., Int J Mol Med 2006
(Stomach Neoplasms) :
BMP-RUNX3 signaling
induces IHH expression in surface differentiated epithelial cells of stomach and intestine
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
Helicobacter pylori infection induces SHH upregulation in parietal cell lineage, while
BMP signals
induce IHH upregulation in pit cell lineage
Katoh et al., Stem Cell Rev 2007
(Disease Progression...) :
BMP signals
induce IHH upregulation in co-operation with RUNX
Katoh et al., Int J Oncol 2009
:
Mesenchymal
BMP induces
IHH expression in gastrointestinal epithelial cells, and then epithelial Hedgehog induces WNT2B and BMP4 expression in mesenchymal cells
Lenton et al., Genesis 2011
:
Moreover, in vitro studies suggest that
Ihh loss
reduces Bmp expression within the calvaria, an observation that may underlie the Ihh-/- calvarial phenotype
Murakami et al., Endocrinology 1997
(Osteosarcoma) :
In sharp contrast to the previous observation of dpp regulation of hedgehog expression in Drosophila embryos,
bone morphogenetic protein-2 did not
affect Ihh expression in these cells