Gene interactions and pathways from curated databases and text-mining

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BMP4 — MAP3K7

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Qiao et al., J Biol Chem 2005 : Transforming growth factor ( TGF ) -beta, bone morphogenetic protein ( BMP ) , and interleukin-1beta activate TGF-beta activated kinase 1 (TAK1) , which lies upstream of the p38 MAPK, JNK, and NF-kappaB pathways
Shim et al., EMBO J 2009 : These findings provide the first in vivo evidence in a mammalian system that TAK1 is required for BMP signalling and functions as an upstream activating kinase for Smad1/5/8 in addition to its known role in regulating MAP kinase pathways
Greenblatt et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : TAK1 mediates BMP signaling in cartilage
Pal et al., Cancer Res 2012 (Breast Neoplasms...) : Conversely, ectopic expression of CCN6 in breast cancer cells antagonized BMP4 mediated TAK1/p38 activation and invasive capacity, both by binding BMP4 protein as well as decreasing BMP4 protein levels
Yumoto et al., J Biol Chem 2013 (Cleft Palate) : Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells, Tak1 is not only required for TGF-ß- and bone morphogenetic protein induced p38 Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads
Yamaguchi et al., Science 1995 : Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein
Shibuya et al., EMBO J 1998 : Role of TAK1 and TAB1 in BMP signaling in early Xenopus development