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BMP4 — MAPK9
Text-mined interactions from Literome
Goswami et al., Dev Biol 2001
(MAP Kinase Signaling System) :
We have examined the
effects of
BMP-4 on
MAPK activity in gastrula ectoderm ... Our findings indicate that
BMP-4 inhibits ectodermal
MAPK activity through a TAK1/p38-type pathway
Viñals et al., FEBS Lett 2002
:
In contrast,
BMP-2 had no effect on p42/p44
MAPK ( Erks ) stimulation
Yang et al., Circ Res 2005
(Hypertension, Pulmonary) :
These differences were not caused by differential activation of BMP signaling pathways because exogenous
BMP-4 led to phosphorylation of Smad1, p38 (
MAPK ), and ERK1/2 in both cell types
Gotoh et al., Mol Cell Biol 2005
:
In addition, experiments are presented demonstrating that
Bmp4 expression in TS cells is controlled by
mitogen activated protein kinase dependent FGF4 stimulation
Otani et al., American journal of physiology. Renal physiology 2007
:
Antagonistic effects of
bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation
induced by aldosterone through
MAPK activation
Leong et al., PloS one 2009
(Osteoporosis) :
These results indicate that protein palmitoylation plays an important role in
BMP induced
MAPK activation, osterix expression, and osteoblast differentiation
Park et al., Blood 2010
(Ischemia) :
A higher proportion of CD34 ( + ) cells ( ~ 20 % ) could be derived from hPSCs by inhibition of
mitogen activated protein kinase ( MAPK ) extracellular signal regulated protein kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling and
activation of
bone morphogenic protein-4 (BMP4) signaling. hPSC derived CD34 ( + ) progenitor cells further developed to endothelial and smooth muscle cells with functionality
Ge et al., J Bone Miner Res 2012
(MAP Kinase Signaling System) :
Significantly, in the presence of AA,
BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally
dependent on
ERK/MAPK activity
Ebeling et al., Reprod Fertil Dev 2011
:
Furthermore,
BMP-6 did not
affect the activity of the
mitogen activated protein kinase
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells, Tak1 is not only required for TGF-ß- and
bone morphogenetic protein induced p38
Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads