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HMGB1 — MAPK7
Text-mined interactions from Literome
Kawahara et al., Cardiovasc Pathol 2008
(Inflammation) :
C-reactive protein
induces high-mobility group box-1 protein release through activation of
p38MAPK in macrophage RAW264.7 cells
Kawahara et al., Int J Mol Med 2008
(Atherosclerosis...) :
The
p38MAPK inhibitor SB203580 and the 5-HT1B antagonist GR55526 markedly
inhibited HMGB1 release from 5-HT stimulated HUVECs ...
HMGB1 induced the activation of
p38MAPK , ERK1/2 and Akt
Oyama et al., Lab Invest 2010
(Granuloma...) :
HMGB1 also
induced MCP-1 secretion through mitogen activated protein kinase (
MAPK ) and phosphoinositide-3-kinase (PI3K) pathways in rat renal tubular epithelial cells in vitro
Zhu et al., Int J Mol Med 2013
:
However, extracellular
HMGB1 , which is actively or passively released under different conditions, can
act as a key inflammatory mediator through
MyD88/mitogen activated protein kinase signaling by binding to its receptors including the receptor for advanced glycation end products or Toll-like receptors
Lu et al., J Interferon Cytokine Res 2013
:
Interestingly, overexpression of Mfn-2 had no marked effect on
HMGB1 mediated
activation of
MAPK , but could attenuate the suppressive effect of HMGB1 on the activity of NFAT