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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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MTOR — YWHAB

Pathways - manually collected, often from reviews:

  • NCI Pathway Database LKB1 signaling events: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1 complex complex (MTOR-MLST8-RPTOR-AKT1S1) (modification, collaborate)
    Shaw et al., Cancer Cell 2004, Gwinn et al., Mol Cell 2008
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database LKB1 signaling events: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1 complex/14-3-3 family complex (MTOR-MLST8-RPTOR-AKT1S1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
    Shaw et al., Cancer Cell 2004, Gwinn et al., Mol Cell 2008
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database LKB1 signaling events: mTORC1 complex complex (MTOR-MLST8-RPTOR-AKT1S1) → mTORC1 complex/14-3-3 family complex (MTOR-MLST8-RPTOR-AKT1S1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
    Shaw et al., Cancer Cell 2004, Gwinn et al., Mol Cell 2008
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database mTOR signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
    Gwinn et al., Mol Cell 2008
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database mTOR signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1/PRAS40/DEPTOR/14-3-3 family complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
    Gwinn et al., Mol Cell 2008
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) → mTORC1/PRAS40/DEPTOR/14-3-3 family complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
    Gwinn et al., Mol Cell 2008
    Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *