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CARD10 — CASP8
Text-mined interactions from Literome
Zhou et al., Proc Natl Acad Sci U S A 1999
:
Direct recruitment and
activation of
caspase-9 by Apaf-1 through the homophilic
CARD/CARD ( Caspase Recruitment Domain ) interaction is critical for the activation of caspases downstream of mitochondrial damage in apoptosis
Shiozaki et al., Proc Natl Acad Sci U S A 2002
:
Oligomerization and activation of
caspase-9 ,
induced by Apaf-1
CARD
Chamaillard et al., Cell Microbiol 2003
(Bacterial Infections...) :
NBS-LRR proteins are characterized by three structural domains : a C-terminal leucine-rich repeat ( LRR ) domain able to sense a microbial motif, an intermediary nucleotide binding site (NBS) essential for the oligomerization of the molecule that is necessary for the signal transduction induced by different N-terminal effector motifs, such as a pyrin domain ( PYD ), a
caspase activating and recruitment domain (
CARD ) or a baculovirus inhibitor of apoptosis protein repeat ( BIR ) domain