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CASP8 — MMP14

Text-mined interactions from Literome

Thomas et al., J Immunol 2000 (Melanoma) : The pan caspase inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) blocked changes in MMP and apoptosis, suggesting that the changes in MMP were dependent on activation of caspase-8
Hu et al., Cancer Chemother Pharmacol 2003 : As ( 2 ) O ( 3 ) induced apoptosis in parent MOLT-4 cells and MOLT-4/DNR cells expressing functional P-gp via depletion of intracellular GSH, and subsequent disruption of MMP and activation of caspase-3
Boya et al., Oncogene 2003 : Inhibition of mitochondrial membrane permeabilization ( MMP ) by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA prevented caspase activation and cell death
Chan et al., J Cell Biochem 2003 (Carcinoma, Squamous Cell) : In this study we demonstrate that curcumin ( Cur ), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential ( MMP ) , mitochondrial release of cytochrome C, caspase-3 activation , and cleavage/activation of PAK2 in A431 cells
Cui et al., Free radical research 2004 : Decrease of mitochondria trans-membrane potential ( MMP ) , release of cytochrome c from mitochondria, and activation of caspase-3 were enhanced after the combined treatment
Park et al., Exp Mol Med 2004 (Carcinoma, Lewis Lung...) : We also observed ceramide/ DMS induced disruption of mitochondrial membrane potential ( MMP ) and activation of caspase- 9 and -3 in a radiation-dose dependent manner
Kwon et al., World J Gastroenterol 2005 (Carcinoma, Hepatocellular...) : Our investigation also showed that SWE induced apoptosis of HepG2 cells were associated with intracellular events including disruption of MMP , increased translocation of cytochrome C from mitochondria to cytosol, activation of caspase-3 , and PARP
Langlois et al., Exp Cell Res 2005 : MT1-MMP mediated caspase-3 activation likely occurs through the mitochondrial pathway since it was abrogated by Bcl-2, but not by CrmA overexpression
Shen et al., Biochem Biophys Res Commun 2006 : Moreover, MMP-2 inhibition reduced Bax expression and caspase3 activity, as well as increasing Bcl2 expression
Chan et al., Hum Reprod 2006 : Using cell culture assay model, we revealed in our results that ginkgolide B treatment of ESCs ( ESC-B5 ) induced apoptosis via reactive oxygen species ( ROS ) generation, c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential ( MMP ) and the activation of caspase-3
Chan et al., Biochem J 2007 : Experiments in embryonic stem cells ( ESC-B5 ) showed that CTN induces apoptosis via ROS ( reactive oxygen species ) generation, increased Bax/Bcl-2 ratio, loss of MMP ( mitochondrial membrane potential ), induction of cytochrome c release, and activation of caspase 3
Grunewald et al., Int J Androl 2008 : Apoptosis signalling was monitored by assessment of EPS, disruption of MMP and activation of caspase-3 by flow cytometry
Song et al., Exp Parasitol 2008 : Incubation of human neutrophils with live trichomonads caused marked receptor shedding of CD16, decrease of mitochondrial membrane potential ( MMP ) and caspase-3 activation in human neutrophils
Choi et al., Biomed Pharmacother 2008 : The sulforaphane induced apoptosis in U937 cells correlated with the generation of intracellular ROS, collapse of MMP , activation of caspase-3 , and down-regulation of anti-apoptotic Bcl-2 expression ... The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against sulforaphane elicited ROS generation, disruption of the MMP , caspase-3 activation and apoptosis
Shin et al., J Microbiol Biotechnol 2008 (Carcinoma, Hepatocellular) : The results of this study demonstrated that streptochlorin mediates ROS production, and that this mediation is followed by a decrease in the mitochondrial membrane potential ( MMP , m ), activation of caspase-3 , and downregulation of antiapoptotic Bcl-2 protein ... The quenching of ROS generation by N-acetyl-L-cysteine administration, a scavenger of ROS, reversed the streptochlorin induced apoptosis effects via inhibition of ROS production, MMP collapse, and the subsequent activation of caspase-3
Yu et al., Apoptosis 2009 (Calcium Signaling) : Significant enhancement of Fas externalization, loss of mitochondrial membrane potential ( MMP ) , and activation of caspase-3 and caspase-8 were observed after the combined treatment
Pandey et al., Int Immunol 2009 (Plague) : Pre-treatment with broad-spectrum caspase inhibitor Z-VAD-FMK, caspase-3 inhibitor Ac-DEVD-CHO and caspase-8 inhibitor Z-IETD-FMK prevented the change in MMP and DNA fragmentation, suggesting caspase dependent apoptosis of rYopJ treated macrophages
Chen et al., Clin Exp Pharmacol Physiol 2010 : In addition, CoCl ( 2 ) ( 600 micromol/L ) enhanced the production of reactive oxygen species ( ROS ) and the expression of cleaved caspase 3, induced a loss of mitochondrial membrane potential ( MMP ) and decreased reduced glutathione ( GSH ) production
Chen et al., Fish Shellfish Immunol 2010 (Birnaviridae Infections) : At 8 h and 12 h p.i., IPNV infected cells demonstrated a dramatic increase in MMP loss, rapid entry into necrotic cell death, and activation of caspase-9 and -3
Chen et al., International journal of molecular sciences 2009 : In the present study, we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation, activation of JNK, loss of mitochondrial membrane potential ( MMP ) , as well as activation of caspase-9 , caspase-3 and PAK2
Ma et al., Am J Transplant 2010 (Reperfusion Injury) : Likewise, MMP-9 inhibition significantly reduced number of TUNEL positive cells and caspase-3 activity, along with decreased protein levels of Fas and Fas-L
Yarbrough et al., J Cardiovasc Pharmacol 2010 (Myocardial Infarction...) : Separate in vitro studies demonstrated that activated caspase species cleaved pro-MMP-2 yielding active MMP-2 forms and that MMP activity was increased in the presence of activated caspase-3
Moon et al., Cancer research and treatment : official journal of Korean Cancer Association 2004 : The CDCA derivatives demonstrated various apoptosis hallmarks, such as mitochondrial changes ( reduction of MMP , cytochrome c release, and Smac/ DIABLO translocation ), activation of caspase-3 ( resulting in the degradation of PARP and DFF45 ), DNA fragmentation and nuclear condensation
You et al., Mol Cell Biochem 2010 (Lung Neoplasms) : SBHA induced apoptosis was accompanied by the loss of mitochondrial membrane potential ( MMP ; d? ( m ) ), Bcl-2 decrease, Bax increase, and the activation of caspase-3
Luo et al., J Control Release 2010 (Prostatic Neoplasms) : The inhibition of caspase-2 activation by small interfering RNA ( siRNA ) knockdown resulted in the significant inhibition of Dtxl-NPs induced disruption of MMP and Dtxl-NPs induced apoptosis, indicating that the activation of caspase-2 was the critical event before the mitochondrial depolarization in the PC3 cells
Yu et al., PloS one 2011 : The apoptosis induction ability of DX1 was associated with the generation of hydrogen peroxide ( H ( 2 ) O ( 2 ) ), a decrease of mitochondrial membrane potential ( MMP ) , and the activation of caspase-8
Choi et al., Chem Biol Interact 2011 (Carcinoma, Renal Cell...) : Cafestol induced apoptosis is associated with the reduction of mitochondrial membrane potential ( MMP ) , activation of caspase 3, cytochrome c release, and down-regulation of anti-apoptotic proteins ( Bcl-2, Bcl-xL, Mcl-1 and cFLIP )
Chan et al., International journal of molecular sciences 2011 : In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial membrane potential ( MMP ) changes, activation of caspase-9 , caspase-3, p21 activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK), and gene expression of p53 and p21 involved in apoptotic signaling
Rao et al., Journal of translational medicine 2011 (Leukemia, Myeloid, Acute) : Curcumin induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein, subsequent loss of MMP , and activation of caspase-3 followed by PARP degradation
Aghaei et al., Prostate 2012 (Adenocarcinoma...) : Furthermore, increase of ROS, loss of MMP , activation of caspase-3 , and down-regulation of Bcl-2 expression was observed
Huang et al., Environ Toxicol 2013 : Further investigation of these processes revealed that MG directly promotes reactive oxygen species ( ROS ) generation, loss of mitochondrial membrane potential ( MMP ) , and activation of caspase-3 , whereas resveratrol effectively blocks MG-induced ROS production and the accompanying apoptotic biochemical changes
Chan et al., International journal of molecular sciences 2011 : Further investigation of these processes revealed that 2-BP directly promotes ROS generation, loss of mitochondrial membrane potential ( MMP ) , and activation of caspase-3 , whereas resveratrol effectively blocks 2-BP induced ROS production and the accompanying apoptotic biochemical changes
Enzenmüller et al., Cancer Lett 2013 (Central Nervous System Neoplasms...) : Addition of the cathepsin B inhibitor CA-074me reduces Bax activation, loss of MMP , caspase-3 activation and cell death upon treatment with GDC-0941/B10
Han et al., Toxicol Lett 2013 (Colorectal Neoplasms) : Sanguinarine generated ROS, which was followed by a decrease in the mitochondrial membrane potential ( MMP ) , the activation of caspase-9 and -3, and the down-regulation of anti-apoptotic proteins, such as Bcl2, XIAP and cIAP-1