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CASP8 — MST1
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Glantschnig et al., J Biol Chem 2002
:
Further activation of
MST1 by caspase cleavage is best
promoted by
caspase-3 , although this appears to be unnecessary for signaling and morphological responses
Ura et al., Mol Cell Biol 2007
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Taken together, our results indicate that
caspase mediated cleavage of
MST1 , followed by MST1 mediated activation of the JNK pathway, is the mechanism responsible for inducing chromatin condensation during apoptosis
Hu et al., Cell Death Differ 2007
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Surprisingly, depletion of
Mst1 triggers
caspase-3 activation, provoking H2B phosphorylation through activating PKC-delta
Wong et al., Nat Cell Biol 2009
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Furthermore, the expression of phosphomimetic histone H2B or
caspase activated
Mst1 immobilizes RCC1 and causes reduction of nuclear RanGTP levels, which leads to inactivation of the nuclear transport machinery ... Therefore, we propose that RCC1 reads the histone code created by
caspase activated
Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus
Lu et al., Sci China Life Sci 2010
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Full inhibition of
caspase-3 activity
reduced Mst1 activation and partially inhibited H2B phosphorylation ( Ser14 ), but ERK1/2, JNK1/2 and p38 activities were not affected
Graves et al., EMBO J 1998
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Caspase mediated cleavage of Mst1 removes the C-terminal regulatory domain and correlates with an increase in Mst1 activity in vivo, consistent with
caspase mediated cleavage activating
Mst1