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CASP8 — NOX1

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Cacicedo et al., Diabetes 2005 (Diabetic Retinopathy) : NAD ( P ) H oxidase appeared to be involved in these responses, since overexpression of dominant negative subunits of NAD ( P ) H oxidase, such as phox47 ( DN ), diminished oxidant stress, and phox67 ( DN ) and N-17 RAC1 ( DN ) prevented the increase in caspase-3 activity
Kim et al., Biochem Pharmacol 2005 (Carcinoma, Hepatocellular...) : Consistently, the stable expression of Nox1-C , a C-terminal region of Nox1 unable to generate ROS, blocked the formation of TUNEL positive apoptotic cells, and activation of caspase-3 and JNK in FaO cells treated with genipin
Qin et al., Free Radic Biol Med 2006 : These results suggest that angiotensin II-induced apoptosis is mediated via NADPH oxidase activation probably through p38 MAPK activation, a decrease in Bcl-2 protein, and caspase activation
Ohtsubo et al., Biochem Biophys Res Commun 2008 : Diphenyleneiodonium, an inhibitor of NADPH oxidase , and N-acetylcysteine, a potent antioxidant, also inhibited TNF-alpha induced activation of Mst1 and caspase 3, as well as apoptosis
Sancho et al., Biochim Biophys Acta 2009 (Carcinoma, Hepatocellular...) : NOX1 and NOX4 targeted knock-down by siRNA experiments suggest that they play opposite roles, because NOX1 knockdown increases caspase-3 activity and cell death, whilst NOX4 knock-down attenuates the apoptotic process
Li et al., Cardiovasc Res 2009 (Disease Models, Animal...) : gp91(phox)-NADPH oxidase mediated calpain-1 activation induces caspase-3 activation and TNF-alpha expression in cardiomyocytes during LPS stimulation
Aguiló et al., Immunol Cell Biol 2010 : Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase dependent NADPH oxidase activation
Sokolovska et al., Nat Immunol 2013 : Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function