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CASP8 — PML
Text-mined interactions from Literome
Giannì et al., Leukemia 1999
(Leukemia, Promyelocytic, Acute) :
In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a
caspase-3 mediated degradation of PML/RARalpha protein and the
PML retargeting on PML-nuclear bodies
Alemany et al., Leukemia & lymphoma 2000
(Leukemia, Megakaryoblastic, Acute...) :
Various mechanisms have been proposed for the As2O3 induced changes in NB4 ( including modulation of
promyelocytic leukemia proteins (PML) and Bcl-2, modification of the glutathione redox system,
caspase activation , and cell cycle arrest ) and are currently under investigation in the megakaryocytic leukemia cell lines
Barbarroja et al., Br J Haematol 2008
(Cell Transformation, Neoplastic...) :
The blockade of MEK/ERK pathway resulted in
caspase dependent degradation of
PML/RARalpha , and attenuation of the cell differentiation induction
Kuwayama et al., Neuro Oncol 2009
(Glioblastoma) :
The overexpression of
PML activated
caspase-8 and induced apoptosis in GBM cells
Wang et al., Nat Genet 1998
(Leukemia, Promyelocytic, Acute) :
Pml is
required for
caspase 1 and caspase 3 activation upon exposure to these stimuli
Mologni et al., Blood 1999
(Leukemia, Promyelocytic, Acute) :
Treatment of APL cells with CD437 is associated with a
caspase dependent degradation of
promyelocytic leukemia-RAR-alpha , which can be completely inhibited by z-VAD