Kim et al., J Biol Chem 2004
(Carcinoma, Hepatocellular...) :
Short interfering RNA mediated inhibition of Smad3 markedly suppressed ALK7 induced caspase-3 activation
Yoshikawa et al., Eur J Pharmacol 2010
(MAP Kinase Signaling System) :
TSA prevented TGF-beta1 induced apoptosis and the activation of caspase-8 and caspase-9 in RPTECs but did not inhibit the TGF-beta1 induced phosphorylation of Smad3 and p38 mitogen activated protein kinase ( MAPK )