Gene interactions and pathways from curated databases and text-mining

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CASP8 — SMAD3

Text-mined interactions from Literome

Kim et al., J Biol Chem 2004 (Carcinoma, Hepatocellular...) : Short interfering RNA mediated inhibition of Smad3 markedly suppressed ALK7 induced caspase-3 activation
Yoshikawa et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : TSA prevented TGF-beta1 induced apoptosis and the activation of caspase-8 and caspase-9 in RPTECs but did not inhibit the TGF-beta1 induced phosphorylation of Smad3 and p38 mitogen activated protein kinase ( MAPK )